A traumatic brain injury is an injury to yourbrain, often caused by a blow to the head. The effects of brain injuries are different for everyone. Your treatment and recovery will depend on the cause of your injury, the location, and how serious it is. Traumatic Brain Injury FAQs Here are...
Longitudinal CBF dynamics in brain regions. (A) Representative regions of interest (ROIs) on a coronal MRI. (B) CBF at lesion cortex shows overall significant difference across both timepoints (6-sessions 0-60dpi,F(5,105) = 2.51, *p = 0.035) and injury condition (Sham vs. TBI...
In the CCI model, injury severity is defined using a priori technical injury parameters, such as impact depth and speed, and a posteriori histological and behavioral outcomes, such as brain tissue loss at the site of primary injury and learning/memory impairments. Specifically, a moderate TBI ind...
Research in the field of traumatic brain injury has until now heavily relied on the use of animal models to identify potential therapeutic approaches. However, a long series of failed clinical trials has brought many scientists to question the translational reliability of pre-clinical results obtained...
While early ROCK2 inhibition with KD025 did not alter the lesion size of the primary (cortical) injury site (Fig. 2G,H), it was modestly neuroprotective at the secondary (hippocampal) injury site (Fig. 2I). Volumes of brain structures in the contralateral hemisphere were not significantly ...
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause severe deficits in meningeal lymphatic drainage that begin within hours and last out to at least one month post-injury...
Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive oxygen species (ROS) production and dysregulated antioxidant mechanisms, which fail to clear excess ROS. This ROS overload promotes the expression of pro-inflammatory genes, releasing cytokines and chemo...
Neutrophils are the first responders among peripheral immune cells to infiltrate the central nervous system following a traumatic brain injury (TBI), triggering neuroinflammation that can exacerbate secondary tissue damage. The precise molecular controls
Traumatic brain injury (TBI) results in activated microglia. Activated microglia can be measured in vivo by using positron emission topography (PET) ligand peripheral benzodiazepine receptor standardized uptake values (PBR28suv). Cell based therapies have utilized autologous bone marrow mononuclear cells ...
Mild traumatic brain injury (mTBI) is a significant health burden among military service members. Although mTBI was once considered relatively benign compared to more severe TBIs, a growing body of evidence has demonstrated the devastating neurological c