The incidence and severity were highest in patients receiving trastuzumab with anthracycline-containing chemotherapy regimens. Evaluate left ventricular function in all patients prior to and during treatment with trastuzumab-qyyp. Discontinue trastuzumab-qyyp treatment in patients receiving adjuvant therapy and...
ImmunotherapyChemotherapyHER2 positiveHER2 breastNCDBApproximately 20% of all breast cancers (BC) are HER2 amplified. In the APT trial, weekly paclitaxel/trastuzumab in node negative HER2+ BC with tumors<3cm was associated with a 7-year invasive disease-free survival of 93%. However, this was in...
Trastuzumab, alone or in combination with chemotherapy, was associated with an improvement in global quality of life in all three studies assessing patients who participated in the major clinical trials. The level of fatigue also improved in patients receiving trastuzumab, alone or in combination with...
L. et al. Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: A retrospective, multicohort analysis. Lancet Oncol. 19, 310–322. https://doi.org/10.1016/S1470-2045(18)30078-0 (2018). Article PubMed ...
HER2 mutation status is not routinely assessed, and these patients are typically treated with standard chemotherapy and/or immunotherapy. Trastuzumab deruxtecan is a HER2 antibody-drug conjugate (ADC) that currently has a breakthrough therapy designation from the FDA for the treatment of patients ...
The prognosis is very poor and no optimal chemotherapy has been established. Human epidermal growth factor receptor 2 (HER2, neu, and erbB2) is highly-expressed in breast cancer and is expressed in many other tumors but poorly expressed in CCA. The anti-HER2 antibody, trastuzumab, has been ...
Trastuzumab is indicated as a first-line treatment, in combination with paclitaxel, for metastatic HER2-overexpressing breast cancer, and as monotherapy in patients who have previously received one or more chemotherapy regimens in the metastatic setting.12 In Europe, trastuzumab can also be used in ...
Besides surgery, radiation, chemotherapy, and endocrine treatment, immunotherapy has become an established part of systemic therapy in treating metastatic ... N Harbeck,MD Pegram,J Rüschoff,... - 《Breast Care》 被引量: 39发表: 2010年 Treatment pattern by hormone receptors and HER2 status in ...
In this multi-center phase II trial, we evaluated the efficacy and safety of a quadruplet regimen (pembrolizumab, trastuzumab, and doublet chemotherapy) as first-line therapy for unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (AGC) (NCT...
A prognostic scoring system for conversion surgery after trastuzumab-based chemotherapy for human epidermal growth factor receptor 2-positive advanced gast... To investigate the clinical indications and prognostic significance of surgical interventions after chemotherapy using trastuzumab-containing regimens for ...