Statistical analysis of multiple amino acid sequence comparisons places the plasma membrane cation-transporting ATPase family in the P-type ATPase superfamily (also known as E1-E2 ATPases). Proteins in this superfamily use the energy of ATP hydrolysis to pump ions across cell membranes....
DltB, a model member of the Membrane-Bound O-AcylTransferase (MBOAT) superfamily, plays a crucial role in D-alanylation of the lipoteichoic acid (LTA), a significant component of the cell wall of gram-positive bacteria. This process stabilizes the cell w
electropotential gradient across the membrane. Cytosolic calcium-binding proteins, calbindins-9k and 28k (CaBP-9k in the intestine and both CaBP-9k and CaBP-28k in the kidney), transport calcium across the cell. Calcium is extruded across thebasolateral membraneinto anextracellular f...
Why is membrane permeability important to the cell? (a) Why are membranes impermeable to most substances? (b) How do proteins function to make membranes selectively permeable? Describe the functions of a cytoplasmic membrane as they relate to permeability. Ex...
Michael Murray6 and Fanfan Zhou1* Abstract Organic anion transporting polypeptides (OATPs) are important transporter proteins that are expressed at the plasma membrane of cells, where they mediate the influx of endogenous and exogenous substances including hormones, natural compounds and ...
Predicting substrates for orphan solute carrier proteins using multi-omics datasets Solute carriers (SLC) are integral membrane proteins responsible for transporting a wide variety of metabolites, signaling molecules and drugs across cellu... Y. Zhang,S. Newstead,P. Sarkies - BMC Genomics 被引量: ...
said chains being each adapted, after the ingoing or outgoing lower part of the conveyor belt, to follow the belt in its rise throughout a complete revolution, whereupon it travels in a direction opposite to the rise of the conveyor belt in a path beside said revolution so as to form the...
The F1F0-ATPase and the electron transport chain proteins can be decoupled by uncoupling proteins that promote the leakage of protons back across the MIM. This is a natural process that results in thermogenesis. The resulting drop in membrane potential reduces ROS production ...
(or organellar luminal) side where copper chelating proteins may accept the metal ion; one via a narrow pathway near the surrounding membrane23or, alternatively, via a larger conduit in the center of the M-domain24. Conversely, ion uptake is likely achieved via a transient entry site, ...
Introduction The members of the organic anion-transporting polypep- tides (OATP) represent a family of important proteins in- volved in the membrane transport of endogenous and xenobiotic compounds. OATP are expressed in a wide vari- ety of tissues, including the liver, kidney, brain, and small...