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Nature Reviews Drug Discovery volume 14, pages 543–560 (2015)Cite this article 26k Accesses 550 Citations 57 Altmetric Metrics details Key Points Membrane transport proteins mediate the transport of molecules across cell membranes and have key roles in human health. More than 100 Mendelian ...
The TMDs forms a translocation path in its center and the residues identified to be involved in substrate interactions are oriented towards an inner cavity of the TMDs and cluster halfway through the membrane (see recent reviews [114], [115], [116]). MDR transporters have the unique ability...
Our intention here is to comment on recent studies with an emphasis on ABCC8 and not reiterate material covered in recent extensive reviews on the muscle-type KATP channels [74, 92, 99, 101, 134, 144]. Background Adenosine-triphosphate-sensitive K+ channels are respon- sive to changes in ...
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Controversies about sugars: Results from systematic reviews and meta-analyses on obesity, cardiometabolic disease and diabetes. Eur. J. Nutr. 2016, 55, 25–43. [CrossRef] [PubMed] 28. Hannou, S.A.; Haslam, D.E.; McKeown, N.M.; Herman, M.A. Fructose metabolism and metabolic disease...