Significance: Vitamin C is a powerful antioxidant that has an intricate relationship with cancer and has been studied for more than 60 years. However, the specific mechanisms that allow malignant cells to uptake, metabolize, and compartmentalize vitamin C remain unclear. In normal human cells, two...
Vitamin C (VC) is an indispensable antioxidant and co-factor for optimal function and development of eukaryotic cells. In animals, VC can be synthesized by the organism, acquired through the diet, or both. In the single VC synthesis pathway described in animals, the penultimate step is catalyse...
Vitamin C (L-ascorbic acid) is an essential nutrient for human health, and its deficiency has long been known to cause scurvy. Sodium-dependent vitamin C transporters (SVCTs) are responsible for vitamin C uptake and tissue distribution in mammals. Here,
All eukaryotic cells and some prokaryotes that are unable to synthesize folic acid utilize membrane-associated transport systems for acquisition of the pre-formed vitamin or its coenzyme forms from external sources. These transport systems, in addition to providing folates essential for cell replication...
Active transport is mainly divided into two types depending on the source of energy: primary active transport in which ATP hydrolysis is linked to drug uphill transport [e.g., P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP)], and secondary active transport in which energy ...
SERUM TRANSPORT OF VITAMIN D 来自 Wiley 喜欢 0 阅读量: 10 作者: None 摘要: Vitamin D3 present in blood serum appears to be associated with a protein fraction having a density of approximately 1.13. Metabolites of vitamin D3, more polar than the vitamin, were detected in dog serum. ...
multivitamin transporter (SMVT). SMVT is a 635amino acid, 12transmembrane domainsodiumsymporterresponsible for the uptake of the water-soluble vitaminsbiotin, pantothenate, andlipoic acidat micromolar concentrations. It has wide tissue distribution and is capable of transporting drug-biotin conjugates ...
Maintenance of colloid osmotic pressure 2. Binding and transport ○ Limits biological activity, distribution, and rate of clearance of different plasma compounds (bilirubin, bile acids, long-chain fatty acids, thyroxin, vitamin D, calcium, magnesium, copper, zinc) ...
The cause of this resistance was found to be an overexpression of a 170 kDa glycoprotein (P170 or P-glycoprotein) in cancer cells. This was the first transporter of this type to be discovered (also known as MRP1). It uses the energy of ATP hydrolysis to extrude hydrophobic compounds from...
Transplasma membrane electron transport in both plant and animal cells activates proton release. The nature and components of the electron transport system