The genes required for the transformation of glucose into gluconate-6-P and its further catabolism via the ED pathway are organized in two adjacent operons. N. meningitidis also contains genes encoding proteins which exhibit similarity to the gluconate transporter (NMV_2230) and gluconate kinase (...
Catabolism of Neu5Gc uses the same pathway as Neu5Ac, likely producing glycolate instead and acetate during its breakdown and catabolism of KDN requires NanA activity, while other components of the Neu5Ac catabolism pathway are non‐essential. We also demonstrate that these two sialic acids can ...
4 (MRP2/4) and breast cancer resistance protein 1 (BCRP), which require ATP for their operation (i.e., they are ABC transporters). Recent studies reveal that OAT4 mediates the reabsorption of urate, the end product of purine catabolism, and the secretion of several drugs (seeFigure 4-6...
(2005) report that toluene stress induced the expression of genes involved in sugar transport, glucose catabolism, and the Krebs cycle, which suggest that the cells are trying to compensate for the high energy expenditure required to survive stress, particularly the ATP cost associated with efflux ...
Focuses on a degrading catabolic pathway for Alzheimer amyloid β-peptide in brain. Functions of transport and catabolism in peptide clearance from t... BS Zlokovic,D Holtzman,J Ghiso,... - 《Nature Medicine》 被引量: 349发表: 2000年 Clearance of amyloid β-protein and its role in ...
Sites and homeostatic control of auxin biosynthesis in Arabidopsis during vegetative growth. Plant J. 28, 465–474 (2001). Article CAS PubMed Google Scholar Ljung, K. et al. Biosynthesis, conjugation, catabolism and homeostasis of indole-3-acetic acid in Arabidopsis thaliana. Plant Mol. Biol....
TREM2 demonstrated improved brain exposure and CNS biodistribution compared to anti-TREM2. ATV:TREM2 promoted mitochondrial metabolic pathways, such as lipid catabolism and glucose oxidation in microglia. In AD mouse models, ATV:TREM2 induced transcription of metabolic pathway genes and increased brain...
The benPK operon, proposed to play a role in transport, is part of a regulon for benzoate catabolism in Acinetobacter sp. strain ADP1. Examines the role of benPK operon in transport of a regulon for benzoate catabolism in Acinobacter sp. strain ADP1. Expression of the genes involved in ...
Catabolism of VLDL by LPL leads to formation of intermediate-density lipoproteins (IDLs), which can either be taken up by the liver or undergo further metabolism to form LDL. Low-density lipoproteins contain apo-B100 and account for 60–80% of the plasma cholesterol in most individuals. ...
Reverse cholesterol transport consists of cellular cholesterol transported from peripheral tissues to the liver, from where it is eliminated in feces as bile acid, cholesterol, and other catabolism products. The cholesterol excreted can also be recycled after intestinal resorption. In the beginning...