The receptor-like protein tyrosine phosphatase DEP1, also known as CD148, is expressed predominantly in epithelial cells, in a variety of tumor cell lines, and in lymphocytes. Expression of DEP1 is enhanced at high cell density, and this observation suggests that DEP1 may function in the ...
In living organisms, cells synergistically couple cascade reaction pathways to achieve inter- and intracellular signal transduction by transmembrane protein receptors. The construction and assembly of synthetic receptor analogs that can mimic such biological processes is a central goal of synthetic biochemistry...
英文名称 Recombinant Human Inactive Tyrosine-protein Kinase Transmembrane Receptor ROR1 , C-6His, Human Cells 英文同义词 Recombinant Human Inactive Tyrosine-protein Kinase Transmembrane Receptor ROR1 , C-6His, Human Cells CAS号 分子式 分子量 0 EINECS号 相关类别 Mol文件 Mol File 结构式 重...
Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase - ScienceDirect Insight into the regulation of the actions of the protein-tyrosine kinases will be greatly facilitated by the full characterization of the family of protei... FR Jirik,NM Janzen,...
Protein Tyrosine Phosphatase Epsilon Regulates Integrin-mediated Podosome Stability in Osteoclasts by Activating Src The nonreceptor isoform of tyrosine phosphatase epsilon (cyt-PTPe) supports osteoclast adhesion and activity in vivo, leading to increased bone mass in fem... S Granot-Attas,C Luxenburg...
Among the top 10 important proteins, there existed a nonTMP drug target P18031 (Tyrosine-protein phosphatase non-receptor type 1). There are 4 TMP drug targets (P00533, P03372, P13569, P05067) among the top 10 important. Fig. 10 Top 10 hub proteins from POSI calculated by Closeness ...
Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome. Marneros A G,Mehenni H,Reichenberger E,Antonarakis S E,Krieg T,Olsen B R. Cytogenetics and Cell Genetics . 2001...
protein–protein interaction receptor tyrosine kinase oligomerization transmembrane domain epidermal growth factor receptor (EGFR) T-cell receptor (TCR) integrin α-helical cell signaling conformational change transmembrane receptor Introduction Membrane receptors transmit information about extracellular stimuli into ...
After tyrosine phosphorylation by src and possibly syk protein tyrosine kinases SIT recruits the SH2 domain–containing tyrosine phosphatase SHP2 via an immunoreceptor tyrosine-based inhibition motif. Overexpression of SIT in Jurkat cells downmodulates T cell receptor– and phytohemagglutinin-mediated ...
unlike the pattern of instantaneous activation and fast fading in soluble cytokine binding receptor tyrosine kinases, collagen binding to DDR1 eliciting a slow and sustainable activation pattern lasting even up to 18 h.24At the present time, it’s not clear about the underlying mechanism that DD...