(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] nickel salt (DGS-Ni-NTA), 1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphocholine (NBD-PC), 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), and phosphatidylinositol-4,5-bisphosphate (PI...
Type II transmembrane serine proteases (TTSPs) are related to tumor growth, invasion, and metastasis in cancer. Genetic variants in these genes may alter their function, leading to cancer onset and progression, and affect patient outcome. Here, 464 breas
transmembrane (C-terminal) protease, serine 12 transmembrane 7 superfamily member 1-like 1 protein Transmembrane Activator and CAML Transmembrane AMPAR regulatory protein gamma-2 Transmembrane AMPAR regulatory protein gamma-3 Transmembrane AMPAR regulatory protein gamma-4 Transmembrane AMPAR regulatory protein ...
GST-SCIMP was used for pull-down assays, along with a protease cleavage and elution strategy24, to optimize capture of genuine binding partners from lysates of activated macrophages. LC/MS/MS analysis of SCIMP-bound proteins in LPS-activated macrophages identified the SFK Lyn and the adaptor ...
BST2, bone marrow stromal antigen 2; HA, hemagglutinin; HEK293T, human embryonic kidney 293T cell line; TMPRSS2, transmembrane serine protease 2; TfR, transferrin receptor. In addition, we tested if zDHHC6 is also able to S-acylate constructs containing only the TMD and adjacent cytosolic ...
Structure of the serine chemoreceptor in Escherichia coli has a relatively simple transmembrane structure that may place limits on the mechanisms available for the transmission of sensory information into the cell.doi... A Boyd,K Kendall,MI Simon - 《Nature》 被引量: 383发表: 1983年 Imitation of...
In summary, we have cloned spinesin/TMPRSS5, a protein that encodes 457 amino acids including a cytoplasmic domain, transmembrane domain, a scavenger receptor-like domain, and a serine protease domain, from human spinal cord mRNA. Spinesin is dominantly expressed at synapses. We predict that ax...
Nevertheless, previous re- search has not addressed whether the TM simply serves to retain the protease on the plasma membrane where the substrates are located or it has an additional role(s) in the regulation of ectodomain shedding. Here we demon- strate that a plasma membrane anchorage signal...
Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease. The C-terminal half of the replicase ORF1a polyprotein of the arterivirus equine arteritis virus is processed by a chymotrypsinlike serine protease...
To biochemically determine whether the NMP was surface-exposed, we found that proteasome subunits in neuronal membranes were susceptible to proteolysis by extracellular application of the broad spectrum serine protease, Proteinase K (PK), to cultured cortical neurons, whereas cytosolic proteasome subunits ...