and “proteins”, (2) confusion resulting from familiar and unfamiliar levels of generality and specificity, (3) conflict resulting from the dual roles of some proteins as participants in and products of translation, and (4) lack of knowledge about the actual origins of amino acids in cells. ...
a transformation in which every point of a geometric figure is moved the same distance in the same direction. Genetics.the process by which amessenger RNAmolecule specifies the linear sequence of amino acids on a ribosome for protein synthesis. Comparegenetic code ( def ). ...
M. The dawn of the age of amino acid sensors for the mTORC1 pathway. Cell Metab. 26, 301–309 (2017). CAS PubMed PubMed Central Google Scholar Dibbens, L. M. et al. Mutations in DEPDC5 cause familial focal epilepsy with variable foci. Nat. Genet. 45, 546–551 (2013). CAS ...
Flexizymes are artificial RNA catalysts that enable us to readily prepare aminoacyl-tRNAs with a variety of amino acid and tRNA kinds. On the other hand, because their flexibility feature lacking high specificities toward amino acids and tRNAs, the in situ aminoacylation in a translation apparatus...
The local tRNA adaptation index (tAI), codon adaptation index (cAI), and the average charge and hydrophobicity of amino acids were all calculated by RiboMiner as described before76. The R package ggpubr86 was used for the plots. Minimum free energies were calculated with RNAfold (ViennaRNA ...
In addition, we demonstrate site-specific and residue-specific labeling of antibodies with fluorescent non-canonical amino acids. In summary, our study describes a novel antibody production platform which combines the highly efficient mammalian protein folding machinery of CHO cells with the benefits of...
The maturation of tRNAs and mRNAs is monitored, as is the identity of amino acids attached to tRNAs. Accuracy is further enhanced during the selection of aminoacyl-tRNAs on the ribosome and their base pairing with mRNA. Recent studies have begun to reveal the molecular mechanisms underpinning ...
The genetic information comprises DNA molecules made up of a sequence of four chemical bases represented by the letters A, T, C and G. The genetic code dictates to the cell which sequence of amino acids to join together to form each protein given the underlying sequence in the DNA. ...
The incorporation of 14C-labelled amino acids into material insoluble in hot TCA under the direction of synthetic polyribonucleotides has been studied in a preincubated, cell-free system from Halobacterium cutirubrum. In the presence of ... ST Bayley,E Griffiths - 《Canadian Journal of Biochemist...
At this conference we show that lipid induced insulin resistance is accompanied by impairments in the ability of amino acids (AA) to stimulate muscle protein synthesis in healthy young men, but the mechanism by which this occurs remains unknown. Here we investigated whether the response of mTOR ...