Lian Z,Pan J,Liu J,et al.The translation initiation factor,hu-Sui1may be a target of hepatitis B X antigen in hepatocarcinogenesis.Oncegene. 1999Lian,Z. et al. (1999) The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis. Oncogene, ...
Moreover, the factor possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40 S subunit. The corresponding gene is found in all eukaryotes and includes an SUI1 domain present also in translation initiation factor eIF1. The versatility of translation ...
Studies on the mof2-1 allele of the SUI1 gene indicate that in addition to its role in recognition of the AUG codon during translation initiation and maintenance of the appropriate reading frame during translation elongation, the Mof2 protein plays a role in the NMD pathway. The Mof2p/Sui1...
SUI1, encoding the smallest subunit of eIF3 (p16), was first identified genetically by recessive mutations that allow utilization of a UUG triplet as a translation initiation codon (13). TIF34 was cloned by obtaining a partial amino acid sequence of p39 and matching it to translated sequences...
2001: Depletion and deletion analyses of eucaryotic translation initiation factor 1A in Saccharomyces cerevisiae Biochimie 83(6): 505-514 Naranda, T.; MacMillan, S.E.; Donahue, T.F.; Hershey, J.W. 1996: SUI1/p16 is required for the activity of eukaryotic translation initiation factor 3 in...
The SUI1 domain, which is also found in eIF1, is involved in the recognition of the translation initiation codon. eIF2D is an initiation factor that was erroneously named ligatin5, but further studies demonstrated that eIF2D and ligatin were two different proteins29. Initially, eIF2D was ...
conditions32,33,34,35,36,37,38,39. Translation initiation is often inhibited via the phosphorylation of the eukaryotic initiation factor 2α (eIF2α)32. We analysed the dynamics of the phosphorylation of eIF2α (yeast Sui2) following treatment of yeast cells with increasing concentrations of H...
However, to successfully implement these compounds as anti-cancer therapeutics, further development of these eIF1-eIF4G1 complex inhibitors, i.e., i14G1s, is required. eIF1A is a 17 KD initiation factor highly conserved among all eukaryotes. eIF1A tails help interact with other initiation ...
SUI1 (coding for eIF1), SUI2 and SUI3 were first identified using a genetic reversion analysis of initiation codon mutations at the HIS4 gene in yeast. This selection procedure was aimed at identifying specific interactions between pre-initiation complex and mRNA that mediate ribosomal recognition...
Initiation factor aIF1A aIF1 tRNA aIF2a–D3–Nterb aIF2a–D12 aIF2b IC0–PREMOTE 6.0 6.9 8.7 8.3 15 ND IC1–PIN 9.3 8.5 10 15.6 15 ND ND, not determined. The table shows the local resolutions in Å of the components of the initiation complexes as determined with RELION using ...