In some embodiments, nucleotides proximal to the 3′-3′ inverted linkage are functionalized with one or more tri-antennary GalNac targeting agents. In some embodiments, the encoding polynucleotides comprise one or more modified nucleotides. In some embodiments, the modified nucleotides are selected ...
Nucleic acid: As used herein, the term “nucleic acid,” in its broadest sense, refers to any compound and/or substance that is or can be incorporated into a polynucleotide chain. In some embodiments, a nucleic acid is a compound and/or substance that is or can be incorporated into a po...