Acta Neuropathologica Communications (2019) 7:31 Page 3 of 17 While recombinant filaments have shed light on many aspects of tau aggregation mechanisms and structure, it is important to note that their formation presents poten- tial biases: (i) the use of an arbitrary cofactor, (ii) the ab...
While recombinant filaments have shed light on many aspects of tau aggregation mechanisms and structure, it is important to note that their formation presents potential biases: (i) the use of an arbitrary cofactor, (ii) the absence of PTMs, (ii) the use of an arbitrary tau segment. Therefor...