To grasp the molecular characteristics of tau structures is challenging. First of all, as a large IDP, tau is flexible and dy- namic and requires high-field nuclear magnetic resonance spectroscopy (NMR) to collect molecular detail. Tau has a low complexity amino-acid sequence, and recently ...
What happens if an amino acid sequence has no stop codon? How many codons are needed to specify three amino acids? What codon starts protein synthesis? Fill in the template strand DNA sequence, mRNA codons, tRNA anticodons, or amino acid sequence. ...
4. determine the amino-acid sequence of a protein during its synthesis by using information on the messenger RNA 5. restate (words) from one language into another language e.g. I have to translate when my in-laws from Austria visit the U.S. Can you interpret the speech of the visiting...
For ex- ample, CACNA1C contains multiple splice sites within exons that lead to small-scale (2–5 amino acid) changes in peptide sequence [7]. To our knowledge, none of the existing nomenclature captures such nuanced events; instead, exons containing alterna- tive splice sites are typically ...
d. Biol. To use (genetic information in messenger RNA) to determine the amino-acid sequence of a protein during its synthesis; also with the RNA as obj.1961Cold Spring Harbor Symp. Quantitative Biol. XXVI. 101/2 This finding implied that the information encoded in DNA must somehow be ...
Historically, ribosomes were viewed as unchanged homogeneous macromolecular machines with no regulatory capacity for mRNA translation. An emerging concept is that heterogeneity of ribosomal composition exists, exerting a regulatory function or specificit
In some embodiments, an mRNA suitable for the invention may encode an amino acid sequence having substantial homology or identity to the wild-type or naturally-occurring amino acid protein sequence (e.g., having at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98% ...
The overall distributions of ribosome footprints on the 5′ UTR, CDS (coding DNA sequence), and 3′ UTR of all protein-coding genes are ∼9%, 90%, and 1%, respectively, and are very similar for all libraries (Figure S3A). We then focused our analysis on the coding region and counte...
Expression: As used herein, “expression” of a nucleic acid sequence refers to one or more of the following events: (1) production of an mRNA template from a DNA sequence (e.g., by transcription); (2) processing of an mRNA transcript (e.g., by splicing, editing, 5′ cap formation...