The expression of fusion gene constructs containing Drosophila regulatory sequences and the structural portions of fish antifreeze protein genes have been examined by transfer into Drosophila melanogaster using P elements. A fusion gene, containing the enhancer, promoter, and cap site of the yolk ...
Unexpectedly, an unstructured A-rich element in 5′ UTRs destabilizes mRNAs in the absence of translation, although it enables cap-independent translation. Our results not only identify diverse sequence features of 5′ UTRs that control mRNA translatability, but they also reveal ribosome-dependent ...
Unexpectedly, an unstructured A-rich element in 5′ UTRs destabilizes mRNAs in the absence of translation, although it enables cap-independent translation. Our results not only identify diverse sequence features of 5′ UTRs that control mRNA translatability, but they also reveal ribosome-dependent ...
In positive-stranded RNA viruses, sequences such as Internal Ribosome Entry Site (IRES) elements, located at the 5′ untranslated region (UTR) of viral mRNAs, are involved in mRNA translation1,2. IRES elements have been described in animal and plant viruses, and also in cellular mRNAs3,4...
Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo. Expression of the rat insulin-like growth factor I (IGF-I) gene results in a number of mature mRNA species that differ in size primarily at the 3' end due to differential polyadenylation site usage...