Second-order phase transition in a SnS orthorhombic crystal under pressureGashimzadeF.M.GuseinovaD.A.JahangirliZ.A.MekhtievingentaconnectPhysics of the Solid State C/c of Fizika Tverdogo Tela
The epithelial-mesenchymal transition (EMT) describes the global process by which stationary epithelial cells undergo phenotypic changes, including the loss of cell-cell adhesion and apical-basal polarity, and acquire mesenchymal characteristics that confer migratory capacity. EMT and its converse, MET (m...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor and is associated with a poor prognosis. Treatment strategies for PDAC are largely ineffective primarily because of delay in its diagnosis and limited efficacy of systematic treatment.
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In 2017, Mekheimer et al. [29] studied the 1,3-dipolar cycloaddition of 2-phenyl-4-arylidene-5(4H)-oxazolone (A2) with C-aryl (or hetearyl)-N-phenylnitrones (A1) in ethanol (Scheme 1). Show abstract 1,3-Dipolar cycloaddition of N-allyl substituted polycyclic derivatives of isoindole...
[143,146,147,148,149,150,151]. In these tumors, treatment with MEK inhibitors resulted in a reduction in EMT-associated proteins and even signs of induction of MET [145,152,153,154]. In pediatric low-grade glioma (LGG), activating mutations of BRAF are common, and confer a worse ...
91. Mottet D, Dumont V, Deccache Y, Demazy C, Ninane N, Raes M, Michiels C: Regulation of Hypoxia-inducible Factor-1α protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/Glycogen Synthase Kinase 3β pathway in HepG2 cells. J Biol Chem 2003, 278:31277–...
Cells were trypsinized and washed twice with 1xPBS prior to cellular fractionation using NE-PER kit from Thermo Fisher according to the manufacturer’s protocol. SILAC labeling and labeling efficiency End1/E6E7 cells were labeled by culturing for 8 passages in SILAC DMEM medium (GIBCO) containing...
In endothelial cells with constitutively active MAPK7 signaling (MEK5D), the abundance of H3K27Me3 is decreased at the promoter regions of miR-200b/a/429 (1.6-fold, p = 0.034; Fig. 4g,h) and miR-200c/141 (1.9-fold, p = 0.035; Fig. 4j,k), implying that MAPK7 ...
14. Grande M, Franzen A, Karlsson JO, Ericson LE, Heldin NE, Nilsson M. Transforming growth factor-beta and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes. J Cell Sci 2002; 115(Pt ...