Instead, it is the compensatory action of the transit-amplifying (TA) cells that changes in aging skin and thus bears responsibility for slowed wound healing.MichaelC.WinterJackieR.BickenbachEBSCO_AspJournal of Investigative DermatologyWinter MC, Bickenbach JR. Aging epidermis is maintained by changes...
Thus, our data indicate that IL-10 reduces the survival of Lgr5+ ISCs and proliferation of epithelial cells by inhibiting Notch and Wnt signaling, but promotes enhanced the differentiation of epithelial cells and expanded numbers of TA cells. Therefore, IL-10 acts as an anti-inflammatory factor...
Stem cells must periodically activate to produce progenitor or transit amplifying (TA) cells that are committed to produce mature cell lineages. Thus, maintaining a balance of stem cell quiescence and activity is a 也适当位置保障免受过份干细胞生产那 能导致癌症。 干细胞必须周期性地激活生产 放大做...
The rate of apoptosis in psoriatic TA cells is significantly lower than in normal TA cells. BDNF or -amyloid fail to induce apoptosis in psoriatic TA cells, and p75NTR retroviral infection restores BDNF- or -amyloid-induced apoptosis in psoriatic keratinocytes. These results demonstrate that p75...
We present evidence that p75NTR is predominantly expressed in TA cells and induces apoptosis in normal human keratinocytes either alone or in association with sortilin. We also show that, even in the presence of Trk, p75NTR can mediate apoptosis, thus overcoming Trk survival signals. Furthermore,...
transit amplifying cellPURPOSE. Single-cell RNA-sequencing (scRNA-seq) was used to interrogate the relatively rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia from wild-type and autophagy-compromised mice.Kaplan, NihalWang, JunyiWray, BrianPatel, Priyam...
Also, loss of Cyclin E and Cdk1 functions in the early germline cells, which decreased the rates of GSC divisions, is suggested to extend the lifespans of GSCs and the TA stages without affecting subsequent differentiation. Similar perturbations at the 4 and 8-cell stages, however, arrested ...
TA cellsEpithelial stem cells within the human hair follicle are critical for hair development, hair cycling, wound healing, and tumorigenesis. We and others have previously shown that the hair follicle bulge area contains keratinocyte stem cells, whereas the hair matrix represents the proliferating ...
We present evidence that p75NTR is predominantly expressed in TA cells and induces apoptosis in normal human keratinocytes either alone or in association with sortilin. We also show that, even in the presence of Trk, p75NTR can mediate apoptosis, thus overcoming Trk survival signals. Furthermore,...