Among the epithelial cells, we identified 3 corneal/limbal epithelial cell subpopulations: Stem/early TA cells, late TA cells, and differentiated corneal epithelial cells. Each population displayed spatially distinct immunostaining patterns. For example, Growth arrest-specific 1 (Gas1) and suppressor of...
We also identified unexpected interactions, particularly a mutual antagonism between IL-4 and EGFR-i in co-regulation of TA cell numbers. Individually, IL-4 or EGFR-i reduced the number of TA cells by ∼4 or ∼6 log-fold relative to control, respectively, while co-treatment reduced the...
Stem cells must periodically activate to produce progenitor or transit amplifying (TA) cells that are committed to produce mature cell lineages. Thus, maintaining a balance of stem cell quiescence and activity is a 也适当位置保障免受过份干细胞生产那 能导致癌症。 干细胞必须周期性地激活生产 放大做...
Epithelial Traffic Control: IL22 Gives TA Cells the Green Light Cellular and Molecular Gastroenterology and Hepatology, Volume 7, Issue 2, 2019, Pages 409-410 Hirohito Abo, Timothy L. DenningView PDFBackground & Aims Epithelial regeneration is essential for homeostasis and repair of the mucosal ba...
The rate of apoptosis in psoriatic TA cells is significantly lower than in normal TA cells. BDNF or -amyloid fail to induce apoptosis in psoriatic TA cells, and p75NTR retroviral infection restores BDNF- or -amyloid-induced apoptosis in psoriatic keratinocytes. These results demonstrate that p75...
TA cellsEpithelial stem cells within the human hair follicle are critical for hair development, hair cycling, wound healing, and tumorigenesis. We and others have previously shown that the hair follicle bulge area contains keratinocyte stem cells, whereas the hair matrix represents the proliferating ...
Instead, it is the compensatory action of the transit-amplifying (TA) cells that changes in aging skin and thus bears responsibility for slowed wound healing.MichaelC.WinterJackieR.BickenbachEBSCO_AspJournal of Investigative DermatologyWinter MC, Bickenbach JR. Aging epidermis is maintained by changes...
transit amplifying cellPURPOSE. Single-cell RNA-sequencing (scRNA-seq) was used to interrogate the relatively rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia from wild-type and autophagy-compromised mice.Kaplan, NihalWang, JunyiWray, BrianPatel, Priyam...
Also, loss of Cyclin E and Cdk1 functions in the early germline cells, which decreased the rates of GSC divisions, is suggested to extend the lifespans of GSCs and the TA stages without affecting subsequent differentiation. Similar perturbations at the 4 and 8-cell stages, however, arrested ...
(Xgo, frequently referred to as medulla glia), and inner chiasm glia (Xgi), both large glial cells that wrap the axon tracts of the two optic chiasmata (Tix et al., 1997, Chotard and Salecker, 2007, Hofmeyer et al., 2008, Edwards and Meinertzhagen, 2010, Hartenstein, 2011, ...