Transient focal ischemiaRodent transient middle cerebral artery occlusion (MCAO) is one of the widely used focal ischemia models. This model mimics human cerebral ischemic injury and provides a unique tool for the mechanistic studies of ischemia in brain tissues in vivo. Rodent ischemia and ...
采用大鼠自体血栓注入脑中动脉法造大脑中动脉阻塞(middle cerebral artery occlusion,MCAO)模型及动脉导管法给药,12 h后对神经功能症状进行评分,计算脑梗死体积,测定出血时间(bleeding time,BT),血清中纤维蛋白(原)降解产物(fibrin degradation product,FDP)含量,血浆中凝血酶时间(thrombin time,TT)、凝血酶原时间(prot...
Background Middle cerebral artery occlusion (MCAo) in mice results in a brain infarct, the volume of which depends on the length of occlusion. Following permanent occlusion, neuropathological changes ??? including a robust glial inflammatory response ??? also occur downstream of the infarct in ...
Reduction of ischemic brain injury by topical application of insulin-like growth factor-I after transient middle cerebral artery occlusion in rats. In order to examine the effect of insulin-like growth factor-1 (IGF-1) on ischemic brain injury, IGF-1 was applied topically on the surface of re...
Transient middle cerebral artery occlusion (MCAO) by an intraluminal thread leads to primarily subcortical infarctions with little sensorimotor impairment in the Wistar rat strain. We investigated the course of infarct development in this lesion type for 10 weeks using magnetic resona...
Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauser-enhanced magnetic resonance imaging.doi:10.1038/jcbfm.2009.84brainimagingischemia--reperfusionnitroxylradicalOverhauser-enhancedMRIoxidativestressredox...
L-NAME Reduces Infarct Volume in a Filament Model of Transient Middle Cerebral Artery Occlusion in the Rat Pup STEPHEN ASHWAL, DANIEL J. COLE, SUZZANNE OSBORNE, TERRILL N. OSBORNE, AND WILLIAM J. PEARCE Departments of Pediatrics [SA ], Anesthesiology [D.l .C., T.N.D., S.D.], and ...
We performed metabolomic analyses of mouse brain using a transient middle cerebral artery occlusion (tMCAO) model with Matrix Assisted Laser Desorption/Ionization (MALDI)-mass spectrometry imaging (MSI) to reveal metabolite changes after cerebral ischemia. We selected and analyzed three metabolites, namel...
We conducted a chronological and comparative analysis of the levels of the electrogenic Na+/HCO3-cotransporter (eNBC) and Na+/H+ exchanger 1 (NHE1) on ischemic penumbra, using the rat model of permanent middle cerebral artery occlusion (... YW Jung,JS Park 被引量: 0发表: 2007年 An Earl...
This study was designed to determine the effect of co-administration of neural like cells (NLC) and acetylsalicylic acid on brain stroke induced by transient middle cerebral artery occlusion. Our findings indicated that MCA occlusion induced severe neural impairment, brain damage and learning and spati...