Production of human lactoferrin and lysozyme in the milk of transgenic dairy animals: past, present, and future Caitlin A. Cooper Elizabeth A. Maga James D. Murray Transgenic Research (2015) Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
These animals exhibit a dose responsive significant association with several chronic inflammatory diseases categorized as Spondyloarthropathies (SpA), a complex of diseases that affect the bowel (IBD), joints and axial skeleton (arthritis), and skin, and which involve the major histoc...
Inhibitors such as antiviral drugs act to block the activity of viral proteins involved in the targeted virus’ entry into, replication within or departure from host cells5, 6; however, there is concern that antiviral drug abuse in farm animals could lead to the growth of antiviral-resistant ...
First, transgenic animals can be used as bioreactors to produce commercially useful compounds by expression of a useful foreign gene in milk or in blood. Many pharmaceutically useful protein factors have been expressed in this way. For example, human 1-antitrypsin, which is commonly used to treat...
mice that produce human growth hormone and pigs that make human hemoglobin sheep that make proteins to help emphysema patients and goats that make proteins to help cystic fibrosis patients All of the above are possible. 1/1 Finish
Administration of GABA reportedly lowers blood pressure in experimental animals (Takahashi et al. 1955), and GABA-enriched products have been found to have hypotensive effects in Dahl salt-sensitive rats and spontaneously hypertensive rats (SHRs) (Abe et al. 1995; Hayakawa et al. 2004), in ...
First, in the study of Macarlupu et al, the control animals were classical WT animals and not littermates, and it is well known that the environmental conditions during the first day of life could induce significant changes in ventilatory variables.91 Second, the method used to measure ...
Although the functionality of such exogenous RNAs in terms of mediating gene expression in animals has been controversial [48, 49], there is enough evidence that such RNAs are capable of translocating from the host to its interacting organism, and vice versa [50]. Overall, there is an ...
aThe copy number of viral RNA in lungs of pangolin-CoV-HKU4-P251T-infected hDPP4 (orange) and WT (blue) mice was determined using qRT-PCR.n = 3 biologically independent animals per genotype for each time point. Data are presented as mean ± SD with scatter plot at each time...
Despite rapid progresses in the genome-editing field, in vivo simultaneous overexpression of multiple genes remains challenging. We generated a transgenic mouse using an improved dCas9 system that enables simultaneous and precise in vivo transcriptional