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At peak lactation, female mice homozygous for the H5 and H6 transgene have approximately twice the amount of mRNA encoding human lysozyme as hemizygous animals. Expression levels of human lysozyme mRNA in the mammary gland at time points representing late pregnancy, early, peak and late lactation ...
Animals had ad libitum access to food and water. The three groups of mice were selected: (1) vehicle-treated mice (ADNS) were administered normal saline (volume was adjusted similar to fasudil treatment); (2) fasudil (ADF) mice were injected daily with fasudil (Tianjin Chase Sun ...
These animals exhibit a dose responsive significant association with several chronic inflammatory diseases categorized as Spondyloarthropathies (SpA), a complex of diseases that affect the bowel (IBD), joints and axial skeleton (arthritis), and skin, and which involve the major histoc...
Inhibitors such as antiviral drugs act to block the activity of viral proteins involved in the targeted virus’ entry into, replication within or departure from host cells5, 6; however, there is concern that antiviral drug abuse in farm animals could lead to the growth of antiviral-resistant ...
First, transgenic animals can be used as bioreactors to produce commercially useful compounds by expression of a useful foreign gene in milk or in blood. Many pharmaceutically useful protein factors have been expressed in this way. For example, human 1-antitrypsin, which is commonly used to treat...
Despite rapid progresses in the genome-editing field, in vivo simultaneous overexpression of multiple genes remains challenging. We generated a transgenic mouse using an improved dCas9 system that enables simultaneous and precise in vivo transcriptional
Both male and female animals were used in this study at equal proportions, however, females were excluded from the study if used as breeders, and males were excluded from the study if infighting or scarring was observed. All animal procedures were performed in accordance with the Institutional ...
Animals were reared at the Tunghai University Animal Care Facility under a 12 h light/dark cycle. The ambient temperature was maintained at 25 °C ± 2 °C and the animals had ad libitum access to food and water. All animal experiments were performed according to good laboratory practice...