Transforming growth factor-beta (TGF-beta), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the ...
Transforming growth factor,beta receptor I (activin A receptor type II-like kinase,53kDa) is a TGF beta receptor.TGFBR1 is its human gene.The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta,transducing the TGF-beta signal from...
aWhat are words ,if they are only for good times,then they don't. 什么是词,如果他们仅是在好时期,然后他们不。[translate] asoothing 安慰[translate] aBrooklyn 布鲁克林[translate] aTransforming growth factor-beta 变换的成长因素beta[translate]...
Transforming growth factor-beta (TGF-beta) and brain tumours. Since its discovery in the late 1970s considerable research has linked transforming growth factor-beta (TGF-β) to several human diseases such as fibrosis,... RB Luwor,AH Kaye,HJ Zhu - 《Journal of Clinical Neuroscience》 被引量...
Transforming growth factor beta (TGFβ) is a cytokine that is secreted by various cell types, including macrophages, and functions in cell growth, cell differentiation, apoptosis and cellular homeostasis by binding to its receptor, the TGFβ type II receptor. Multiple signalling pathways lie downstre...
in the absence of Transforming Growth Factor beta (TGF-β) signaling in thymocytes, negative selection is significantly impaired. Highly autoreactive thymocytes first escape cortical negative selection and acquire a Th1-like-phenotype. They express high levels of CXCR3, aberrantly accumulate at the cor...
Transforming Growth Factor betaCrystallography, X-RayAmino Acid SequenceConserved SequenceModels, MolecularTransforming growth factors were identified on the basis of their ability to induce soft agar growth and morphological changes in nonmalignant cells. The original observation was of an activity,......
TGF-β modulates growth factor receptor expression The ability of TGF-β to modulate the expression of cytokine receptors has been observed both in transformed cell lines and in normal hematopoietic progenitors. In murine progenitor cell lines, TGF-β has been shown to down-modulate the expression ...
A new type of transforming growth factor-beta, TGF-beta 3. A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been d... R Derynck,PB Lindquist,A Lee,... - 《Embo Journal》 被引量...
Recent studies implicate the transforming growth factor beta (TGF-β) superfamily as playing a major role in bone formation. Nothing is currently known about the function of vgr-1 (also called Bone Morphogenetic Protein-6, or BMP-6), a TGF-β-like protein that localizes to hypertrophic cartil...