In addition to the density of TRs on the tumor cell surface, the efficacy of Tf-toxin conjugate is influenced both by the Tf-iron saturation state and by the presence of free diferric Tf in the tumor microenvironment. The affinity of Tf-Saporin (Tf-SO6) to TR was greatly diminished whe...
Also, Tfr2α localizes in lipid raft domains on the exosomal cell membrane, where it is internalized by clathrin-mediated endocytosis, if transferrin saturation (TS) is low [49]. Tfr2α protein regulation occurs mainly through its stabilization on the cell membrane as a consequence of the ...