Transferrin Saturation (TS) TS is usually reported along with the serum iron (SI) and total iron binding capacity (TIBC). TS indicates the percent of iron binding sites on transferrin that are carrying iron. TS is derived from a calculation using the formula: TS =(SI/TIBC) x 100 TS resu...
Blood samples for determination of serum iron, ferritin, and transferrin levels were collected and calculation of the transferrin saturation index was performed before drug administration at 8 am on the first day of the study (when patients had been fasting), on day 8 (13 hours after the last...
Tf saturation and iron binding site occupancy can be determined by the urea gel electrophoresis method first developed by Makey and Seal [145], [146]. Common results with the blood serum of healthy individuals reveal an apparent contradiction with the described thermodynamic preference for iron bind...
2.9. Calculation of TSAT (%) The method used routinely to calculate TSAT in most reports measures iron and Tf in serum, but this method is indirect and subject to misleading results [29]. Direct assessment of transferrin saturation combining electrophoretic U-PAGE [30] (that separates Tf into...