the transferrin levels were either low between 40 and 70 mg/l with low transthyretin (<17,8 mg/l)(n=6) or high (>400 mg/l) with transthyretin levels between 200 and 400 mg/l (n=12).No relationship to any clinical parameters (extension of the detachment, onset of symptoms or degre...
To elucidate the role of transferrin in atherosclerotic lesion development, the effects of transferrin overexpression and knockdown on the development of AS and hypercoagulability were evaluated. Transferrin expression levels were first validated by qRT-PCR and western blot (Supplementary information, Fig....
Conversely, administration of ATf iv to reduce TSAT at the onset of reperfusion (17–25%, Low TSAT) reduced the infarct volume in the two transient stroke models tested. Importantly, serum Tf levels we measured in the experimentally-induced High and Low TSAT rats doubled those of normal ...
Indirect bilirubin was initially 25.2 mg/dl, LDH 2367 U/l and reticulocytes 4.4 %; haptoglobin and transferrine levels were correspondingly low. A ... B Walz,B Riecken - 《Deutsche Medizinische Wochenschrift》 被引量: 12发表: 2008年 Transferrin, C(3) Complement, Haptoglobin,Plasminogen and α...
ProINS-Tf also demonstrated a better glucose-lowering effect than native insulin, even with a much lower dose and less frequent injections, in non-obese diabetic mice with insulin resistance symptoms. The activated ProINS-Tf, serving as a bivalent protein molecule, could be a new insulin analog...
39 The mice exhibit symptoms similar to those of patients with MPS II,39 which warrants their use as a model of MPS II. The generation of TFRC-KI mice is described in Figure S1 and the Supplemental Materials and Methods. To obtain TFRC-KI/Ids-KO double-mutant mice, Ids-KO mice were ...
2014-12-25上传 (1222)89Zr-labeled human antitransferrin receptor monoclonal antibody as a PET probeas,a,AS,human,Human 文档格式: .pdf 文档大小: 545.24K 文档页数: 9页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类:
evident from the intracellular stability assay. Further, we showed that these drug loaded QDs were localized in the late endosomal compartment and exhibited no symptoms of cytotoxicity and genotoxicity on the host cells. Results Characterization of the Zn-RIF complex...
Dosing of such an antibody could be modulated such that acute clinical symptoms could be minimized (ie, by dosing at a very low dose or at widely-spaced intervals), as well-understood in the art.Anti-TfR/BACE1 and anti-TfR/Abeta are each promising and novel therapeutic candidates for the...
Even if patients with hemochromatosis maintain low serum levels of ferritin, they still have an increased risk of general and joint symptoms, which reduce quality of life. This could be related to persistently increased transferrin saturation. We assessed whether duration of exposure to increased ...