In contrast, the uptake of 131I-labeled rat serum albumin increased linearly with concentration, and there was no difference between control and iron-deficient livers. It is concluded that iron deficiency leads to an increase in the number of high-affinity transferrin receptors and receptor-mediated...
iron-deficient humans, rabbits, pigs, horses, and cattle (Furugouri, 1972;Halvorsen and Halvorsen, 1973;Harveyet al., 1987a;Miltenburget al., 1992b;Mollerberget al., 1975). A slight increase in serum TIBC was reported in an experimental study of diet-induced iron deficiency anemia in ...
It was proposed in a previous report in the 1980s that iron deficiency would be protective against CHD as a potential explanation for the differences in CHD risk between men and women.39However, two studies have well documented that iron deficiency is associated with an increased risk of cardiov...
However, the diagnosis of iron deficiency is not always easy in such patients. Recent studies have shown that the serum transferrin receptor (s-TfR) level is a sensitive, quantitative measure of tissue iron deficiency. In this study, we examined the changes in s-TfR levels in patients with ...
each having a high affinity reversible binding site for Fe3+. The iron is transported in blood and interstitial fluids to sites of use and disposal. Iron/transferrin is essential in haemoglobin synthesis and for certain types of cell division. Serum concentration rises in iron deficiency and pregn...
Diagnosis of iron deficiency anemia in the elderly by serum transferrin receptor The diagnosis of iron deficiency anemia (IDA) in the elderly is difficult because of the prevalence of chronic diseases, which can cause anemia with high f... E Rimon,A Sapir,Z Shteger,... - 《European Journal...
Bone structural and mechanical properties are affected by hypotransferrinemia but not by iron deficiency in mice.[erratum appears in J Bone Miner Res 2000 Aug;15(8):1641] This article discusses a study on the regulation of transferrin recycling kinetics by phosphatidylinositol 4,5-bisphosphate avail...
Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). Transferrin has a molecular weight of around 80 kiloDaltons and contains 2 specific high-affinity Fe(III) binding ...
Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). Transferrin has a molecular weight of around 80 kiloDaltons and contains 2 specific high-affinity Fe(III) binding ...
Note that high concentrations of FAC (>0.4 mM) were toxic to the mutants. In contrast, the increased HIF activity in FLCN−/− cells was reversed by FAC to a level similar to that in control cells (Fig. 5D). Moreover, iron deficiency (+DFO) induced HIF activity more strongly than...