aPOD apical point of departureBPA bisphenol ABMD benchmark doseDES diethylstilbestrolEDC endocrine disrupting chemicalResource limitations often require risk assessors to extrapolate chronic toxicity from acute tests using assessment factors. Transcriptomic dose-response analysis following short-term exposures ...
Temporal concordance between apical and transcriptional points of departure for chemical risk assessment Toxicol. Sci., 134 (2013), pp. 180-194 CrossrefGoogle Scholar Tocher and Glencross, 2015 D.R. Tocher, B.D. Glencross Lipids and fatty acids C.S. Lee, C. Lim, D.M. Gatlin III, C....
The lowest concentrations leading to more than 25% loss of viability were designated as point of departure (POD). 1,2-DCVC was found to decrease viability in all tested systems with RPTEC/TERT1, HepaRG and LUHMES as the most sensitive models with the lowest POD of 62.5 µM (Fig....
The test provides a p-value for each gene pair, representing its departure from this expectation (Methods). The scale parameter d is user-configurable, allowing the user to probe the spatial texture at different scales, though in practice it is ultimately limited by spatial resolution of the ...
those genes that not only showed departure from neutral models of sequence evolution, but those that also showed strong evidence of positive selection (elevated dn/ds) on the branch leading toH. desmarestianus.Such genes show divergence of theH. desmarestianussequence from the other two species ...
exposure concentrations and quality control on processed cDNA libraries for sequencing, concentration‐response modeling was applied to the data sets for 18 of the tested compounds, and the concentration at which a concerted molecular response occurred (transcriptomic point of departure; tPOD) was ...
A key step in assessing the potential human and environmental health risks of industrial and agricultural chemicals is to determine the toxicity point of departure (POD), which is the highest dose level that causes no adverse effect. Transcriptomic POD (tPOD) values have be...
It is postulated that below a transcriptomic-based point of departure, adverse effects are unlikely to occur, thereby providing a chemical concentration to use in screening level hazard assessment. The present study extends previous work describing a high-throughput fathead minnow assay that can ...
point of departurePer- and polyfluoroalkyl substances (PFAS) are a large class of chemicals of concern for both human and environmental health because of their ubiquitous presence in the environment, persistence, and potential toxicological effects. Despite this, ecological hazard data are limited to...
Point of departureradiationrisk assessmentbenchmark dosePurpose Benchmark dose (BMD) modeling is used to determine the dose of a stressor at which a predefined increase in any biological effect above background occurs (e.g. 10% increase from control values). BMD analytical tools have the ...