Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes. Understanding the regulation of Nrf2 activity and downstream pathways has major implications for human health.Tonelli, ...
Inhibition of the NRF2/KEAP1 Axis: A Promising Therapeutic Strategy to Alter Redox Balance of Cancer Cells Emiliano Panieriand Luciano Saso Vol. 34, No. 18May 2021 An Overview of Autophagy: Morphology, Mechanism, and Regulation Katherine R. Parzychand ...
In fact, a recent study using knockout mice indicated that the NF-E2-related factor 2, Nrf2, was part of a transcriptional complex directly involved in mediating the transcriptional regulation of the mouse Gst A1 gene (14). Furthermore, using in vitro gel shift assays, these investigators ...
By analyzing the FST gene proximal promoter, we identified a putative antioxidant response element (ARE), which is a consensus Nrf2-binding sequence (Fig. 4D). To determine the direct regulation of Nrf2 on FST expression, the luciferase reporters containing FST promoters with either wild-type or ...
Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML). Posttranscriptional regulation by microRNAs (miRNAs) can affect the
NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival A. Rushworth, "NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival," ... Shah...
cdd NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival NM Shah1,2, L Zaitseva1, KM Bowles1,3, DJ MacEwan2,4 and SA Rushworth*,1,4 Transcription factor NRF2 is an important regulator of oxidative stress....
MSCs have three different differentiation fates — adipocytes, osteoblasts, and chondrocytes — which are regulated by different genes. In the differentiation process, some cells in the three differentiation pathways also have a reciprocal transformation relationship through the regulation of related genes,...
The induction of FST transcription was mediated by the nuclear factor erythroid 2-related factor 2 (Nrf2), as evidenced by the decreased FST expression in Nrf2- deficient cells and the direct binding of Nrf2 to FST promoter region. Down-regulation of FST promoted SiO2 NP-induced apoptosis both...
Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species 2006, Advances in Enzyme Regulation Nrf2-Keap1 defines a physiologically important stress response mechanism 2004, Trends in Molecular Medicine Show abstract Transcriptional Regulation by Nrf2 2018, Antioxida...