Algorithm: ward2).bH2A.Z transcript between HCC tissues and normal liver tissues was analyzed in the publicly accessible samples(TCGAhttp://gepia.cancer-pku.cn/;T = 375,N = 50)(Software: beeswarm, R package).cScatter plots comparing H2A.Z expression...
misregulationoftheseTFscanresultintheacquisitionoftumor- relatedproperties(3).Forexample,E2F1isoverexpressedinmany cancertypesandpromotestumorproliferationbyregulatingex- pressionofgenesinvolvedincelldifferentiation, metabolism, and development (4). As another example, FOXM1 plays an important ...
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Recent progress in our understanding of transcription and its role in cancer pathogenesis suggests that many new insights will soon be leveraged for patient benefit. Thus, the bulk of the phenotypes, including those affecting their clinical progression and therapeutic responsiveness, are likely to be ...
In addition, the pathway of transcriptional misregulation in cancer was overrepresented (Fig. 2g). Download: Download high-res image (2MB) Download: Download full-size image Fig. 2. Differential transcription factor activity between normal prostates and primary prostate cancers. (a–e) Activity ...
B, nodulation (NOD)-like receptor, mitogen-activated protein kinase (MAPK), Jak-STAT, HIF-1 and adipocytokine ones. KEGG pathways connected with transcriptional misregulation in cancer and microRNAs in cancer are also present in the list of upregulated genes, indicating that the role of...
(Fig.2E, Supplemental Table6). Functional annotation of the159 genes that were continuously repressed in response to SB431542, and therefore were stimulated by autocrine TGF-β signaling, revealed TGF-β pathway signaling (as expected), transcriptional misregulation in cancer, and FoxO and Ras ...
MLL leukemia is caused by the rearrangement of MLL genes at 11q23, which generates various MLL chimeric proteins that promote leukemogenesis through transcriptional misregulation of MLL target genes. Biochemical studies on MLL chimeras have identified that the most common partners exist in the super...
Table 1 eRNAs with confirmed functions in diseases Full size table eRNAs in cancer Enhancers play specific roles in human cells, and their mutations or misregulation can lead to the occurrence of malignant tumors. Therefore, it would be crucially important to understand whether the eRNAs produced by...
Functional enrichment analysis showed that mRNAs co-expressed with six lncRNA biomarkers were enriched in many known cancer-related pathways such as the cGMP–PKG signaling pathway, Apelin signaling pathway, Focal adhesion, and transcriptional misregulation in cancer (Fig. 2D). These results ...