In brief, the RNA polymerase together with certain transcription factors binds to the DNA promoter. This causes the part of the DNA to unwind and form a transcription bubble. A site in the transcription bubble binds to the RNA polymerase. A phase of abortive cycles of short mRNA transcripts ...
Many transcription factors regulate gene expression in a lineage- and process-specific manner, despite being expressed in several cell types. Here, the authors show that the Hox transcription factor Ubx has lineage-specific interactomes, which contribute to its cell context-dependent functions. Julie ...
Transcription factors bind RNA through an Arg-rich motif; these interactions potentially promote transcription and development, and their dissociation can contribute to disease. Eytan Zlotorynski Research Highlights20 Jul 2023 Nature Reviews Molecular Cell Biology Volume: 24, P: 604 Measuring the imp...
Hitoshi Kurumizaka, in Trends in Cell Biology, 2024 Transcription elongation factors Conserved proteins known as transcription elongation factors, including Spt4/5, Spt6, Elf1, Spn1, and the Paf1 complex (Paf1C) in yeast (DSIF, SPT6, ELOF1, IWS1, and PAF, respectively, in mammal...
The MYB superfamily constitutes one of the most abundant groups of transcription factors described in plants. Nevertheless, their functions appear to be highly diverse and remain rather unclear. To date, no genome-wide characterization of this gene famil
(eg,cyclin T1). P-TEFb phosphorylates NELF, which dissociates, and DSIF, which then promotes transcription as an elongation factor throughout the rest of transcription. P-TEFb can form a large “super elongation complex” in combination with other elongation factors and chromatin regu...
Transcription factor, molecule that controls the activity of a gene by determining whether the gene’s DNA is transcribed into RNA. Transcription factors control when, where, and how efficiently RNA polymerases, which catalyze the reactions that synthesi
Transcription in eukaryotes is more complicated than in prokaryotes. First, the RNA polymerase of higher organisms is a more complicated enzyme than the relatively simple five-subunit enzyme of prokaryotes. In addition, there are many more accessory factors that help to control theefficiencyof the in...
Transcription factors (TFs) are key regulatory proteins that enhance or repress the transcriptional rate of their target genes by binding to specific promoter regions (i.e. cis-acting elements) upon activation or de-activation of upstream signaling cascades. TFs thus constitute master control elements...
Transcription factors BrlA, AbaA and WetA constitute the core regulatory pathway of NC in Aspergillus nidulans [9]. Disrupting any of these three genes can block conidiation [10,11,12]. In addition, upstream regulatory genes, such as FluG and FlbA-E, also regulate the core regulatory pathway...