Transcription factors bind RNA through an Arg-rich motif; these interactions potentially promote transcription and development, and their dissociation can contribute to disease. Eytan Zlotorynski Research Highlights20 Jul 2023 Nature Reviews Molecular Cell Biology Volume: 24, P: 604 Measuring the imp...
Here, using spatiotemporal gene ablation in murine hair follicles, we uncover a critical role for the transcription factors (TFs) nuclear factor IB (NFIB) and IX (NFIX) in maintaining SC identity. Without NFI TFs, SCs lose their hair-regenerating capability, and produce skin bearing striking ...
Transcription factors (TFs) bind to the DNA regulator sequence to regulate plant growth and development. They can also boost plant tolerance to abiotic and biotic stressors by orchestrating regulatory networks. The MYB family is a prominent TF family in eukaryotes that regulates a variety of biologi...
The shoot apical meristem (SAM), from which all above-ground tissues of plants are derived, is critical to plant morphology and development. In maize (Zea mays), loss-of-function mutant studies have identified several SAM-related genes, most encoding homeobox transcription factors (TFs), located...
Hitoshi Kurumizaka, in Trends in Cell Biology, 2024 Transcription elongation factors Conserved proteins known as transcription elongation factors, including Spt4/5, Spt6, Elf1, Spn1, and the Paf1 complex (Paf1C) in yeast (DSIF, SPT6, ELOF1, IWS1, and PAF, respectively, in mammal...
Transcription in eukaryotes is more complicated than in prokaryotes. First, the RNA polymerase of higher organisms is a more complicated enzyme than the relatively simple five-subunit enzyme of prokaryotes. In addition, there are many more accessory factors that help to control theefficiencyof the in...
Journal2016,Fungal Biology Reviews Lori B.Huberman, ...N. LouiseGlass Accessory transcription factors Two accessory transcription factors inT. reesei, ACE1 and ACE2, were originally identified from a yeast one-hybrid screen that promoted activation of a selectable marker tethered to the promoter of...
Transcriptome analyses using microarray technology, together with conventional approaches, have revealed that dozens of transcription factors (TFs) are involved in the plant response to drought stress [4, 9, 10]. Most of these TFs fall into several large TF families, such as AP2/ERF, bZIP, NAC...
Many transcription factors regulate gene expression in a lineage- and process-specific manner, despite being expressed in several cell types. Here, the authors show that the Hox transcription factor Ubx has lineage-specific interactomes, which contribute to its cell context-dependent functions. Julie ...
We assessed whether additional factors beyond SOX9 motif type could modulate RE sensitivity to SOX9 dosage among its direct targets. We focused on binding by other TFs, specifically TWIST1, NR2F1 and TFAP2A, as they have well-known roles in CNCCs and their binding in hESC-derived CNCCs ha...