Zinc finger domains of the Cys2-His2family have been most promising for the construction of artificial transcription factors due to their modular structure. Each domain consists of approximately 30 amino acids and folds into a ββα structure stabilized by hydrophobic interactions and chelation of a...
Specifically, researchers observed that some regions of the genome undergoing increased methylation tend to have binding sites for transcription factors that are downregulated, or have low expression. In some types of colon cancer, based on the types of genetic alterations associated with the cancer, ...
to terminate Pol III transcription, thus allowing efficient RNA release and delivery of reinitiation-competent Pol III; iii) the retention of Pol III on the same gene for multiple transcription cycles through facilitated recycling; iv) the involvement in Pol III transcription of ancillary factor...
We propose that this versatile geometric pattern answers to two regulatory requirements: the segregation of euchromatin into an active and an inactive compartment, as well as a large interface between these compartments to facilitate access of transcription factors to activate target genes when needed. ...
Fig. 21.5.Assembly of the transcription initiation complex (schematic). First, TFIID binds to the DNA double helix in the TATA box of the promoter site, then the other factors attach approximately in the indicated order. The polymerase complex locates the polymerase in the correct position. As ...
Transcription Factors for RNA Polymerase II The complexity of eukaryotic transcription does not end with the polymerases and promoters. An army of basal transcription factors, enhancers, and silencers also help to regulate the frequency with which pre-mRNA is synthesized from a gene. Enhancers and si...
Damages to the corneal epithelium trigger important changes in the composition of the extracellular matrix to which the basal human corneal epithelial cells (hCECs) attach. These changes are perceived by membrane‐bound integrins and ultimately lead to re‐epithelialization of the injured epithelium ...
Transcription Factors | Definition, Functions & Types from Chapter 18 / Lesson 5 22K What are transcription factors? This lesson will define transcription factors, discuss their functions, and their unique classes. Related to this QuestionWhat...
3), thereby increasing the probability that Pol III will re-attach to the same transcription unit [8]. In humans, putative Pol III reinitiation factors have been identified. In particular, the La auto-antigen is thought (although not without controversy) to act as a transcript release fact...
AXIN2 is a direct target of a complex that includes TCF/LEF transcription factors and β-catenin29. To determine whether the β-catenin –TCF/LEF complex is implicated in AXIN2 induction by SS18-SSX1, we expressed a dominant negative (ΔN) mouse LEF-1 mutant, which lacks the β-catenin...