Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such observations requires quantitative studies of TF dosage effects at trait-relevant ranges, largely lac
Site-specific transcription factors (TFs) bind DNA regulatory elements to control expression of target genes, forming the core of gene regulatory networks. Despite decades of research, most studies focus on only a small number of TFs and the roles of man
Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing. Nat. Immunol. 10, 1102–1109 (2009). Article CAS PubMed PubMed Central Google Scholar Benson, M.J. et al. Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and ...
TFIIA-like factor DPE: downstream promoter element DRE: DNA replication element DREF: DRE-binding factor Inr: initiator element NURF: nucleosome remodeling factor PCNA: proliferating cell nuclear antigen PIC: pre-initiation complex SL1: selectivity factor 1 SNAPc: snRNA activating protein...
Vullhorst D, Buonanno A (2005) Multiple GTF2I-like repeats of general transcription factor 3 exhibit DNA binding properties. Evidence for a common origin as a sequence-specific DNA interaction module. J Biol Chem 280(36):31722–31731 PubMed CAS Google Scholar Gupta M, Mungai PT, Goldwasser...
Id proteins play crucial roles in cell differentiation and proliferation by acting downstream of many signaling pathways, such as transforming growth factor b and bone morphogenic protein signaling pathways (Ruzinova and Benezra, 2003). Like Id, ILI1 and PRE1 seem to function as non- DNA ...
These findings suggest that a CREB family member acts cooperatively with an additional transcription factor(s) to regulate BDNF transcription. We conclude that the BDNF gene is a CREB family target whose protein product functions at synapses to control adaptive neuronal responses....
QIAGEN 9013430 Maintenance kit, semi annual, BR9600 (D) QIAGEN 9238809 Round carrier for 4 Falcon tubes 50ml QIAGEN 9238806 Round carrier for 9 Falcon tubes 15ml QIAGEN 9019664 PyroMark Vac Prep Worktable, PyroQ96VW QIAGEN 9019652 O rings - VPT Filter Probe, PyroQ96VW ...
Transcription factor RFX1 is crucial for maintenance of genome integrity in Fusarium graminearum . Eukaryot. Cell 13, 427–436 (2014). Article Google Scholar Kiriyama, M., Kobayashi, Y., Saito, M., Ishikawa, F. & Yonehara, S. Interaction of FLASH with arsenite resistance protein 2 is ...
[194,195]. It is possible that the influence of FoxO3 activity differs with different stages of the disease. Interestingly, Vidal and colleagues unveiled a new mechanism of FoxO function in HD, where the loss of the unfolded protein response (UPR) transcription factor XBP1 leads to augmented ...