Figure 1. Whisper architecture diagram. A transformer model "is trained on many different speech processing tasks, including multilingual speech recognition, speech translation, spoken language identification, and voice activity detection. All of these tasks are jointly represented as a sequence...
Multiple protein to DNA interactions on the proximal SP-C promoter contribute to regulation of SP-C transcription. The configurations of known cis-active regulatory elements are diagramed relative to thetranscription start site(arrow). Boxed regions labeled C1 to C5 denote sites of protein-DNA...
Glioblastomas (GBMs) are highly aggressive, infiltrative, and heterogeneous brain tumors driven by complex genetic alterations. The basic-helix-loop-helix (bHLH) transcription factors ASCL1 and OLIG2 are dynamically co-expressed in GBMs; however, their combinatorial roles in regulating the plasticity...
The genome of phage T4 consists of 160 kbp of double-stranded DNA and is highly compressed; for example, promoters and translation control sequences are nested within the coding regions of overlapping upstream genes. The presence of introns in bacteriophage genomes, which are under constant ...
A Schematic of a mature HIV-1 particle in cross-section, with protein layers labeled (generated from BioRender). B Geometric model for the arrangement of CA subunits in the mature viral capsid. The CA hexamers are colored green and pentamers blue. Diagram adapted from [16]. C Structure of...
we required that the predicted target genes also show an overall expression level above the threshold TPM > 1. Additionally, these genes must overlap with the GRN generated by GENIE3 using gene-expression and translation levels as previously described [42,73]. The regulatory weight is the ...
Fig. 1: Alleles ofBBX18and their transcriptional activation activities. aSchematic diagram ofBBX18alleles. There were two nucleotide changes in the coding region between SpBBX18 from wild tomato (S. pennelli) and SlBBX18 from cultivated tomato species (S. lycopersicum). The C328T change would...
and 120 h, with three biological replicates for each embryonic stage, labeled Em1d-Em5d. Total RNA was extracted using Trizol reagent kit (Invitrogen, Carlsbad, CA, USA) according to the manufacturer’s protocol. The RNA concentration and purity were measured using the Nano-Drop 2000 spectrophot...
Nitric oxide (NO) is a diffusible signaling molecule that modulates animal and plant immune responses. In addition, reactive nitrogen species derived from NO can display antimicrobial activities by reacting with microbial cellular components, leading to
Remarkably, translation (i.e., ribosomal subunits and translation factors) was by far the top pseudotime-downregulated pathway (Figure 1G), suggesting its importance during differentiation.23 Using pseudotime as a measurement of differentiation, we evaluated the ability of each TF ORF to direct ...