This article is categorized under: RNA Processing > Splicing Mechanisms RNA Processing > Splicing Regulation/Alternative Splicing The production of mRNA relies on the crosstalk between the transcriptional machinery, the chromatin, and the spliceosome. Physical interactions and feedback loops promote two﹚...
The disrupted RNA processes increase the FS transcripts generated by RNA splicing errors and the insertions and deletions (INDELs) of MSs22. Both of these processes, combined with the disrupted quality control system in tumor cells, can lead to the production of FS peptides and exposure of the...
▸RNA splicing = processing the RNA to remove regions that will not be included in the final protein; ▸Export = preparing the processed RNA to be moved into the cytosol and translated into protein; ▸Translation = building of a protein according to the sequence of the messenger RNA; ...
Heterogeneous ribonucleoproteins (hnRNPs) are RNA binding molecules that are involved in key processes such as RNA splicing and transcription. One such hnRNP protein, hnRNP L, regulates alternative splicing (AS) by binding to pre-mRNA transcripts. However, it is unclear what factors contribute to ...
Subsequent splicing optimization correlates with increasing Ser-2 phosphorylation of the RNA Pol II carboxy-terminal domain (CTD) and activation of the positive transcription elongation factor (pTEFb). Thus, rapid de novo recruitment of RNA Pol II dictates the course of events during Tcell activation...
Introns & Exons | RNA Splicing & Processing8:30 RNA to Amino Acids | Genetic Code Translation, Definition & Codon7:03 Genetic Code & How to Read a Codon Chart7:22 Anticodon Creation, Translation & Example9:23 The Role of Ribosomes and Peptide Bonds in Genetic Translation7:39 ...
The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing. Estrogen receptor beta (ERβ) is endowed with oncosuppressive...
protein–protein interaction isothermal titration calorimetry (ITC) RNA splicing protein structure RNA-binding protein protein domain gene regulation Introduction Tat stimulatory factor 1 (Tat-SF1)4 was originally identified as a host cofactor that activates Tat-directed HIV-1 transcription (1, 2). Sub...
55、的催化的RNARNA合成合成3.2 RNA3.2 RNA聚合酶聚合酶I I识别的启动子识别的启动子3.3 Pol3.3 Pol识别的启动子识别的启动子3.4 RNA3.4 RNA加工加工(1) Capping (5 端加帽)端加帽)(2) Polyadenylation (3 端多聚腺苷酸化)端多聚腺苷酸化)(3) RNA splicing (RNA 剪接剪接)(4) Editing (RNA编辑)编辑...
RNA Polymerase IITranscription, GeneticAlternative SplicingAlternative splicing regulation not only depends on the interaction of splicing factors with splicing enhancers and silencers in the pre-, but also on the coupling between and splicing. This coupling is possible because splicing is often co...