Human cancer-derived cell lines have been widely used as preclinical cancer models in cancer biology research and anti-cancer drug discovery16. Massive efforts have been made to delineate the molecular characteristics across large-scale cancer cell lines17. The Cancer Cell Line Encyclopedia (CCLE) pr...
for estimating gene counts accounts for differences in isoform lengths that could otherwise lead to false gene DE reporting under situations where it is differential transcript usage (DTU) as opposed to differential gene expression (DGE) occurring. SeeSoneson et al., F1000 Research, 2016for details...
The function “convert_transcriptID” then needs to be executed in R (Command 1) with either default options or user-chosen options. To illustrate the mapping of a transcript to genomic locations in TransAT, we selected transcripts from 3 PDAC patients (Table 1a, b) as an example. Table ...
For example, some disease mechanisms involve regulating expression in a tissue-specific manner or during a particular stage of development. This level of specificity and transcript diversity is not within the scope of the MANE Select set. Furthermore, when generating the MANE Plus Clinical set, we...
s also a possibility. And we do know that in challenging situations where people are socially isolated, for example, there is great research that’s come out now looking at lockdown during COVID at the beginning of COVID. And especially for example, individuals who feel more isolated and ...
Once a transcript has been finalized, members of the research team read it in its entirety, which enables them to get the “big picture” of the interview. This also helps them learn about wording and phrasing that are particular to the individual being interviewed and to get an overall sens...
Storing events supports reliable propagation of application state, because if the events are in a sequence, then others can then follow that sequence. See, for example, the notification log design from Vaughn Vernon. The big question I had was how applicable event sourcing really...
The mechanisms of f-circRNAs in tumorigenesis have not been thoroughly described in literature, but have been considered important in future research and exploration (Huang et al., 2019). In vitro and in vivo models have assisted in determining that f-circRNAs have oncogenic features (Zhou et al...
Both have their pros and cons which we explained in the section below. Human Services vs Automated Software Automated software is computer programs that listen to your file and type out what they hear. A very basic example of this is Google’s speech to text function on Google docs. ...
What do you find in your research? Does it become a pattern people can’t get out of? Tessa West Absolutely. And I think this is where things start to get dangerous. There’s a little bit of a people-pleasing creep that happens. Your boss says, I just need some last minute help wi...