Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before. In this study, we investigated the effect of TC on kainic acid-...
Interestingly, we also proved that TC's effects on these mechanisms are dependent on the type 2 cannabinoid receptor. Taken together, the results of this study show that TC exerts anti-inflammatory effects in TNF-α-stimulated chondrocyte models....
In HepG2 cells transfected with small interfering RNA of PPAR-α, the effects of trans-caryophyllene on PPAR-α responsive gene expressions, intracellular triglyceride, fatty acid uptake and oxidation were disappeared. These results indicate that the aroma compound, trans-caryophyllene, is PPAR-α ...
The present invention mitigates blood triglyceride using plant source cloves alkene and being prepared for drug has few side effects in a conventional inhibin drug to meeting desired consumer. The present invention also provides the risks that the nutritional supplement alkene containing cloves reduces ...
Therefore, the trans-caryophyllene provides effects of skin regeneration and wrinkles improvement. The trans-caryophyllene provides anti-oxidant effect by inhibiting free radical generation, anti-inflammation effect by inhibiting nitrogen oxide (NO) generation, and skin whitening effect by reducing the ...
The effects of β-caryophyllene oxide and trans-nerolidol on the efficacy of doxorubicin in breast cancer cells and breast tumor-bearing mice. Biomed. Pharmacother. 2017, 95, 828-836. [CrossRef]
Importantly, TC's effects on inhibiting the activation of NF-κB and the secretion of inflammatory cytokines can be abolished by muting the CB2R using small RNA interference. These observations indicate that TC suppresses the hypoxia-induced neuroinflammatory response through inhibition of NF-κB ...
the latter was evaluated in C2C12 cells first pretreated with CB2 receptor antagonists, AM630 and SR144528 (5 µM, preincubation for 2 h), then stimulated with BCP 10 nM. Both inhibitors abrogated the effects of BCP, suggesting that its insulin-mimetic effect was dependent on the CB2 recep...
Trans-caryophyllene (TC), a major component in the essential oils derived from various species of medicinal plants, has displayed its neuro-protective effects in previous studies. However, whether TC has a protective role in AD remains unknown. In this study, the effects of TC on Aβ 1–42...