DrugInteraction Integrate drug-drug interactions in your software 1,2-Benzodiazepine The risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Tramadol. Abacavir Tramadol may decrease the excretion rate of Abacavir which could result in a higher serum level. ...
Inhibitors of CYP2D6: Potential pharmacokinetic interaction (increased plasma tramadol concentrations, decreased plasma M1 concentrations). Increased tramadol concentrations may increase or prolong therapeutic effects and increase risk of adverse effects (e.g., seizures, serotonin syndrome); decreased M1 ...
Life-threatening respiratory depression and death have occurred in children who received tramadol. Tramadol and codeineare subject to variability inmetabolismbased upon CYP2D6genotype(described below), which can lead to increased exposure to an active metabolite. Based upon postmarketing reports with trama...
Cytochrome P450 3A4 Interaction The concomitant use of tramadol hydrochloride tablets with cytochrome P450 3A4 inhibitors, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritonavir) or discontinuation of a cytochrome...
Cytochrome P450 3A4 Interaction The concomitant use of ULTRAM with cytochrome P450 3A4 inhibitors, such asmacrolideantibiotics (e.g.,erythromycin),azole-antifungalagents (e.g., ketoconazole), andproteaseinhibitors (e.g., ritonavir) or discontinuation of a cytochrome P4503A4 inducer such as rifampin...
CYP450 3A4 inhibitors/inducers and CYP450 2D6 inhibitors: Interactions are complex, consult drug interaction monographsSafe Reduction or Discontinuation of Therapy in Patients who may be Physically Dependent:Discontinuation/reduction plans should be individualized and take into consideration multiple factors ...
CYP450 3A4 inhibitors/inducers or CYP450 2D6 inhibitors: Interactions are complex, consult drug interaction monographsIn circumstances in which physical dependence has occurred, do not abruptly discontinue this drug.Use a gradual downward taper Precautions...
Intervention: Frequently reevaluate the prothrombin time of patients on warfarin for signs of an interaction and adjust the dosage of warfarin as needed. Drug Abuse And Dependence Controlled Substance CONZIP contains tramadol, a Schedule IV controlled substance. Abuse CONZIP contains tramadol, a substa...
Tricyclic antidepressants (TCAs), and other tricyclic compounds (e.g., cyclobenzaprine, promethazine, etc.), Other opioids. Tramadol hydrochloride extended-release tablets Monoamine Oxidase (MAO) inhibitors [see WARNINGS; Use with MAO Inhibitors and Serotonin Re-uptake Inhibitors and PRECAUTIONS; Drug...