DrugInteraction Integrate drug-drug interactions in your software 1,2-Benzodiazepine The risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Tramadol. Abacavir Tramadol may decrease the excretion rate of Abacavir which could result in a higher serum level. ...
Does tramadol interact with my other drugs? Enter medications to view a detailed interaction report using our Drug Interaction Checker. Drug name Add a drug to check interactions Add StorageStore at room temperature away from moisture and heat and out of reach of children. Do not share with ...
Inhibitors of CYP2D6: Potential pharmacokinetic interaction (increased plasma tramadol concentrations, decreased plasma M1 concentrations). Increased tramadol concentrations may increase or prolong therapeutic effects and increase risk of adverse effects (e.g., seizures, serotonin syndrome); decreased M1 ...
Life-threatening respiratory depression and death have occurred in children who received tramadol. Tramadol and codeineare subject to variability inmetabolismbased upon CYP2D6genotype(described below), which can lead to increased exposure to an active metabolite. Based upon postmarketing reports with trama...
Interaction With Central Nervous System (CNS) Depressants ULTRAM ER should be used with caution and in reduced dosages when administered to patients receiving CNS depressants such as alcohol, opioids, anesthetic agents, narcotics, phenothiazines, tranquilizers or sedative hypnotics. ULTRAM ER increases ...
CYP450 3A4 inhibitors/inducers and CYP450 2D6 inhibitors: Interactions are complex, consult drug interaction monographsSafe Reduction or Discontinuation of Therapy in Patients who may be Physically Dependent:Discontinuation/reduction plans should be individualized and take into consideration multiple factors ...
CYP450 3A4 inhibitors/inducers or CYP450 2D6 inhibitors: Interactions are complex, consult drug interaction monographsIn circumstances in which physical dependence has occurred, do not abruptly discontinue this drug.Use a gradual downward taper Precautions...
Cytochrome P450 3A4 Interaction The concomitant use of ULTRAM with cytochrome P450 3A4 inhibitors, such asmacrolideantibiotics (e.g.,erythromycin),azole-antifungalagents (e.g., ketoconazole), andproteaseinhibitors (e.g., ritonavir) or discontinuation of a cytochrome P4503A4 inducer such as rifampin...
Intervention: Frequently reevaluate the prothrombin time of patients on warfarin for signs of an interaction and adjust the dosage of warfarin as needed. Drug Abuse And Dependence Controlled Substance CONZIP contains tramadol, a Schedule IV controlled substance. Abuse CONZIP contains tramadol, a substa...
In vitrodrug interaction studies in human liver microsomes indicate that concomitant administration with inhibitors of CYP2D6 such as (fluoxetine paroxetine, and amitriptyline could result in some inhibition of the metabolism of tramadol. Quinidine ...