Western philosophy stands as a cornerstone of human intellectual history, with its roots stretching back to ancient civilizations. Its origins are embedded in a rich tapestry of cultural interactions, pre-scientific inquiries, and the exploration of fundamental questions about existence, knowledge, and e...
Curiosity concerning the process of human creation has been around for a long time. Relevant questions seemed to be resolved with the knowledge of how cells divide after fertilization obtained through in vitro fertilization experiments. However, we still
Hosey asserts that the first 98 percent of human existence was spent on the African savanna, where acacia trees dominate the horizon. Combined with Wilson's quote about our genetic origins, people therefore are drawn to images that merge with our hardwired preference for fractallike forms — for...
Understanding the molecular and cellular processes involved in lung epithelial regeneration may fuel the development of therapeutic approaches for lung diseases. We combine mouse models allowing diphtheria toxin-mediated damage of specific epithelial cell types and parallel GFP-labeling of functionally dividing...
The recent realization that brown fat exist in adult humans suggests increasing brown fat energy expenditure could be a therapeutic strategy to combat obesity. To understand adipose tissue development, several groups are tracing the origins of mature adipocytes back to their adult precursor and ...
The documentary mode has not had the recognition it deserves in the western historiography of Japanese cinema. The ‘discovery’ of that cinema at film festivals in Europe and the United States in the 1950s, and the growth of academic and popular writing that followed, prioritized aesthetic and...
Molecular clock estimation, together with analysis of their environmental distribution, phenotypic diversity, and concordance with host fossil records, place the origins of the enterococci around the time of animal terrestrialization, 425–500 mya. Speciation appears to parallel the diversification of ...
Genomic organisation of extinct lineages can be inferred from extant chromosome-level genome assemblies. Here, we apply bioinformatic and molecular cytogenetic approaches to determine the genomic structure of the diapsid common ancestor. We then infer th
Heterotrimeric G proteins are fundamental signaling proteins composed of three subunits, Gα and a Gβγ dimer. The role of Gα as a molecular switch is critical for transmitting and amplifying intracellular signaling cascades initiated by an activated G
Neuroanatomical tracing methods remain fundamental for elucidating the complexity of brain circuits. During the past decades, the technical arsenal at our disposal has been greatly enriched, with a steady supply of fresh arrivals. This paper provides a landscape view of classical and modern tools for...