Tissue stem cells are generated from a population of embryonic progenitors through organ-specific morphogenetic events1,2. Although tissue stem cells are central to organ homeostasis and regeneration, it remains unclear how they are induced during development, mainly because of the lack of markers that...
After severe skin damage, the resulting scar usually contains dense extracellular matrix (ECM) fibers devoid of the hair follicle (HF) and sebaceous gland (SG), which lack sensation and endocrine function as well as the flexibility of normal skin1. As a result, there is an urgent need to e...