The tetratricopeptide repeat (TPR) motif is one of many repeat motifs that form structural domains in proteins that can act as interaction scaffolds in the formation of multi-protein complexes involved in numerous cellular processes such as transcription, the cell cycle, protein translocation, protein...
The TPR domain is postulated to play an important regulatory role in subcellular positioning of AGS3 through interaction with binding partners perhaps also influencing AGS3 interaction with G-protein. We asked which regions of the TPR domain may be of particular importance regarding this regulatory ...
The tetratricopeptide repeat-domain of the PAS10 protein of Saccharomyces cerevisiae is essential for binding the peroxisomal targeting signal-SKL. All TPR-containing proteins involved in diverse processes like mitosis or RNA-synthesis share the ability to interact with other proteins. Here we show .....
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX home
The receptor kinase BR INSENSITIVE1 (BRI1) transduces brassinosteroid (BR) signal by phosphorylating members of the BR-signaling kinase (BSK) family of RLCKs, which contain a kinase domain and a C-terminal tetratricopeptide repeat (TPR) domain. Here, we show that the BR signaling function of ...
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Ramsey AJ, Russell LC, Chinkers M (2009) C-terminal sequences of Hsp70 and Hsp90 as non-specific anchors for tetratricopeptide repeat (TPR) proteins. Biochem J 423:411–419 Ratajczak T, Carrello A (1996) Cyclophilin 40 (CyP-40), mapping of its Hsp90 binding domain and evidence that FKB...
Protein phosphatase 5 (PP5) is auto-inhibited by intramolecular interactions with its tetratricopeptide repeat (TPR) domain. Hsp90 has been shown to bind PP5 to activate its phosphatase activity. However, the functional implications of binding Hsp70 to PP5 are not yet clear. In this study, we ...
These unstable features may be essential for the tetratricopeptide-repeat-containing proteins to mediate a wide range of protein-protein interactions. Further CD experiments were used to evaluate the binding of TPR1 to the c-terminal peptides of hsc70 and hsc90. Size exclusion column and DSS ...
analyzed by TMT-assisted mass spectrometry. Note that the loss of TPR results in diminished abundance of TREX-2 complex subunits (GANP and PCID2) to the NPC but does not affect their total protein amount. Data represent a repeat of one experiment.d–gTargeting of GANP and NXF1 to the ...