产品名称:TPO受体激动剂(Avatrombopag) 英文名称:Avatrombopag 产品货号:M04638 产品规格:1mL(10mM)|5mg|10mg|50mg|100mg Avatrombopag(AKR-501;AS1670542)是血小板生成素受体(TPO受体)的新型具活性激动剂,EC50值为3.3nM。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!
2. 中华医学会血液学分会血栓与止血学组. 促血小板生成药物临床应用管理中国专家共识(2023年版). 中华血液学杂志,2023,44(07):535-542. 3. Jurczak W, Chojnowski K, Mayer J, et al. Phase 3 randomised study of avatrombop...
3. Jurczak W, Chojnowski K, Mayer J, et al. Phase 3 randomised study of avatrombopag, a novel thrombopoietin receptor agonist for the treatment of chronic immune thrombocytopenia. Br J Haematol. 2018 Nov;183(3):479-490. 4. Mei H, Zhou H, Hou M, Sun J, Zhang L, Luo J, Jiang ...
Kuter DJ. The structure, function, and clinical use of the thrombopoietin receptor agonist avatrombopag. Blood Rev. 2022;53:100909. https://doi.org/10.1016/j.blre.2021.100909. Epub 2021 Nov 16. PMID: 34815110. Article CAS PubMed Google Scholar Tsykunova G, Ghanima W. Avatrombopag ...
This phase 4, multicenter, open-label study was conducted to evaluate the safety, efficacy, and treatment satisfaction of switching to avatrombopag from another thrombopoietin receptor agonist (TPO-RA) in patients with immune thrombocytopenia (ITP). Adults who had received ≥90 days of treatment ...
参考文献:Ziqi Wan et al. Avatrombopag, a promising novel thrombopoietin receptor agonist for refractory/relapsed/intolerant non-severe aplastic anemia: a phase 2 single-arm clinical trial. Ann Med. 2023 Dec;55(1):222404...
3.Jurczak W, Chojnowski K, Mayer J, et al. Phase 3 randomised study of avatrombopag, a novel thrombopoietin receptor agonist for the treatment of chronic immune thrombocytopenia. Br J Haematol. 2018 Nov;183(3):479-490. 4. Mei H, Zhou H, Hou M, Sun J, Zhang L, Luo J, Jiang ...
3. Jurczak W, Chojnowski K, Mayer J, et al. Phase 3 randomised study of avatrombopag, a novel thrombopoietin receptor agonist for the treatment of chronic immune thrombocytopenia. Br J Haematol. 2018 Nov;183(3):479-490. 4. Mei H, Zhou H, Hou M, Sun J, Zhang L, Luo J, Jiang...
Efficacy and safety of avatrombopag in the treatment of chemotherapy-induced thrombocytopenia: A retrospective study [J]. Tumor, 2021, 41(12): 832-839. [18] 黄月华, 张苗苗, 李利红, 等 . 艾曲泊帕在实体肿瘤化疗 所致血小板减少症治疗中的应用 [J]. 肿瘤研究与临床, 2020, 32(9): 652-654....
8. Al-Samkari H, Kolb-Sielecki J, Safina SZ, et al. Avatrombopag for chemotherapy-induced thrombocytopenia in patients with non-haematological malignancies: an international, randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet Haematology 2022; 9 (3): e179-e189. doi: ...