Lecithin - An Emulsifier for Parenteral Use: TORVS Research Team Skolnik, P.; Eaglstein, W. H.; Ziboh, V. A. (Jul 1977). "Human essential fatty acid deficiency: treatment by topical application of linoleic acid". Archives of Dermatology. 113 (7): 939–941. doi:1...
Treatment of gastrointestinal fistulas with a combination of TPN and somastostatin or somastostatin analogue Xu Baohua,Yin Lu,Ren Jian an et al Research Institute of General Surgery,Nanjing General Hospital of PLA(Nanjing,210002) Abstract Objectives:Post surgical gastrointestinal fistula is a frequent...
A possible mechanism responsible for the gratifying results of TPN treatment may be the increased tolerance for 5-FU resulting from improved nutrition and increased cell-mediated immunity.doi:10.1002/bjs.1800700508Yamada, N.Koyama, H.Hioki, K....
TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH)[1]. PDE5|0.62 nM (IC50) [1]. Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 ...
[1].Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2019 May 23;62(10):4979-4990. ...
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH). TPN171 was proven to exert a longer lasting effect than sildenafil in animal models, providing a foundation for ...
The tail gas is mainly chlorine, hydrogen chloride and nitrogen, which can be partially recycled or completely removed from the tail gas recovery treatment system. It is also possible to spray liquid carbon tetrachloride into the trap, and chlorothalonil is condensed out after contact with the ...
近日,沈敬山、蒋华良、朱维良、许叶春和阿吉艾克拜尔·艾萨研究团队在期刊Journal of Medicinal Chemistry上发表了题为Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesteras Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension的封面...
当然第二种的还需要强调的就是feature fusion,原文的最后一句也强调了要careful treatment! 2.Spatial Semantic Modulation: 也就是框架中的第二个框框,作用就是上面提到的要把这些来自不同depth的feature map进行spatial domin上的对其,或者说整合,毕竟大家都有差异,那么如何让其和平共处就显得格外重要了。这里自己有...