The TPMT gene is important for the metabolism of thiopurine drugs used in the treatment of various conditions. The variant, which involves an in-frame deletion and insertion event, was found to be specific to th
全称 thiopurine S-methyltransferase 别名 Thiopurine S-methyltransferase, EC:2.1.1.67 计算分子量 28 kDa 观测分子量 28-32 kDa GenBank蛋白编号 BC005339 基因名称 TPMT Gene ID (NCBI) 7172 RRID AB_2272030 偶联类型 Unconjugated 形式 Liquid 纯化方式 Antigen affinity purification UNIPROT ID P51580 储存缓...
Thiopurine S-methyltransferase (TPMT) is required for detoxification, through S-methylation, of 6-thioguanine nucleotides (TGNs), a byproduct of thiopurine metabolism. Catalog#10682-1-AP is a rabbit polyclonal antibody raised against the full-length of human TPMT. TPMT has a predicted molecular ...
6-MP intolerance is mostly associated with a deficiency in the activity of the en- zymes thiopurine S-methyltransferase (TPMT) [8] and inosine triphosphate pyrophosphohydrolase (ITPA) [9], which are related to the metabolism of 6-MP, and © The Author(s). 2018 Open Access This article ...
Thiopurine methyltransferase (TPMT) and inosine triphosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs: azathioprine and 6-mercaptopurine, used in the treatment of leukemia or inflammatory bowel diseases (IBD). The activity in these enzymes correlates with the genetic ...
Genetic variation in thiopurine S-methyltransferase (TPMT) is a major factors for wide variation in the metabolism and safety of thiopurine drugs. We investigated the frequency of functional gene polymorphisms in 396 patients with inflammatory bowel disease and 300 healthy subjects. Frequencies of ...
Thiopurine S-methyltransferase geneDrug metabolismPharmacogeneticsBackground: Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs that are commonly used to treat a wide range of conditions. It is now well established that interpatient variation in sensitivity to these ...
Thiopurine S-methyltransferase (TPMT) is required for detoxification, through S-methylation, of 6-thioguanine nucleotides (TGNs), a byproduct of thiopurine metabolism. Catalog#10682-1-AP is a rabbit polyclonal antibody raised against the full-length of human TPMT. TPMT has a predicted molecular ...