参考文献: [1]Sun M, Chen J, Xue Y, Deng Y, Van Mater D, Hiemcke-Jiwa LS, Wu P, Fang Y. Poor outcome in congenital mesoblastic nephroma with TPM3::NTRK1 fusion: a case report from multi-disciplinary treatment to molecular tumor board. Transl Pediatr. 2024 Jun 30;13(6):976-986...
Description TPM3, tropomyosin 3, is a member of the tropomyosin family of actin-interacting proteins, which regulates actin function and plays an essential role in embryonic development (PMID: 23904035, PMID: 26240174). TPM3-NTRK1 fusions are recurrent in colorectal cancer, and additional fusions ...
TPM3-NTKR1 fusionBloom syndrome (BS) is a genomic and chromosomal instability disorder with prodigious cancer predisposition caused by pathogenic variants in BLM . We report the clinical and genetic details of a boy who first presented with infantile fibrosarcoma (IFS) at the age of 6months and...
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Familial Cancer (2022) 21:85–90 https://doi.org/10.1007/s10689-020-00221-1 SHORT COMMUNICATION Infantile fibrosarcoma with TPM3‑NTRK1 fusion in a boy with Bloom syndrome Sue M. Huson1 · Timo Staab2 · Marta Pereira1 · Heather Ward1 · Roberto ...
AI-Edigene® TPM3(E7)-NTRK1(E10) Fusion询价产品描述 产品数据库CBP20141R Format RNA Description TPM3, tropomyosin 3, is a member of the tropomyosin family of actin-interacting proteins, which regulates actin function and plays an essential role in embryonic development (PMID: 23904035, PMID...
TPM3-NTRK1 fusionEarly recognition and characterization of soft tissue tumors is important for proper fetal and maternal care. Here, we present sonographic, fetal and postnatal MRI, and pathological findings of a rare case of congenital NTRK-rearranged malignant spindle cell sarcoma with TPM3-NTR...
Pan-TRK immunohistochemistry was positive, FISH revealed an NTRK1 translocation and next-generation sequencing confirmed an NTRK1-TPM3 fusion. Postoperative CT revealed no residual tumour and the patient was placed under close surveillance. Nine months later, the patient presented with vaginal bleeding....
Molecular diagnosis revealed c-KIT and PDGFRa wild type with TPM3-NTRK1 fusion, unfortunately this patient had a rapidly progressive disease and passed away. This case highlights the gene mutation in the molecular characteristics of NTRK-RSCNs, and the significance of accu...
Herein, we present an acquired TPM3-NTRK1 fusion resistant to larotrectinib in lung adenocarcinoma with EML4-ALK fusion progressed on lorlatinib.Case Presentation: A 48-year-old male with stage IV adenocarcinoma of lung with metastatic disease of bone was initially treated with carboplatin, ...