他们在食管癌 组织中都存在一定的表达率,表达率分别为41.37%,32.76%,20.69%和37.93%.化疗有效组患者与化疗无效组患者相比较,食管癌组织中 PgP,GSH和MRP的阳性表达率低,TP阳性表达率高,两组之间有显著性差异.结论:食管癌组织中PgP,TP,GST-π,MRP存在一定的表达 率;PgP,GST-π,MRP表达率低而TP表达率高,化疗...
2.2 食管癌中PgP、TP、GST-π、MRP的表达与化疗疗效的关系 58例患者在第2个疗程结束后3 wk进行化疗疗效评价, 其中缓解者(完全缓解及部分缓解)有41例, 有效率为70.69%(41/58); 无缓解者17例(无变化及进展), 占29.31%. 分析有效组患者和无效组患者癌组织中PgP、TP、GSH、MRP的表达情况: PgP在有效组中(完...
病例分析:仅从免疫组化是不能诊断乳腺癌的，还需要胸部ct，钼靶检查，乳腺超声等。意见建议:确诊后，应...
respectively.Compared to patients not responding to chemotherapy,the positive rates of PgP,GSH and MRP expression were significantly lower and that of TP was significantly higher in patients having response to chemotherapy.CONCLUSION:Low expression of PgP,GST-π,and MRP and high expression of TP are...
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The GSTP1*C allele has an additional transition from C to T. For GSTM1 as well as GSTT1, the polymorphic allele is a deletion of the gene. The proportion of individuals homozygous for the GSTP1 variant alleles ( GSTP1*B/*B, GSTP1*B/*C and GSTP1*C/*C ) was significantly ...
www.nature.com/scientificreports OPEN GSTP1 and GSTO1 single nucleotide polymorphisms and the response of bladder received: 08 January 2015 accepted: 31 July 2015 Published: 10 September 2015 cancer patients to intravesical chemotherapy Xiaheng Deng*, Xiao Yang*, Yidong Cheng*, Xuzhong ...
The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility Mohammad Reza Safarinejad, Nayyer Shafiei and Shiva Safarinejad The effects of the GST genes (GSTM1, GSTT1 and GSTP1) on male factor infertility have not been well elucidated...
Genetic polymorphism of GSTM1andGSTP1in lung cancer in Egypt. Maggie M. Ramzy,Mohei El-Din M. et al. International Journal of Collaborative Research onInternal Medicine&Public Health (IJCRIMPH) . 2011Ramzy MM, Solliman MM, Abdel-Hafiz HA, Salah R. Genetic polymorphism of GSTM1 and GS...
Influence of GSTM1, GSTT1, GSTP1, and EPHX gene polymorphisms on DNA adduct level and HPRT mutant frequency in coke-oven workers, Mutat. Res. 431 (1999) 259-269.Viezzer C, Norppa H, Clonfero E, Gabbani G, Mastrangelo G, Hirvonen A and Celotti L (1999) Influence of GSTM1, ...