We describe an ongoing dose-escalation study of tissue plasminogen activator (tPA) as ultra-early therapy for cerebral infarction. The protocol requires that hemorrhage be ruled out by computed tomography scan of the brain prior to tPA infusion, and the infusion must begin within 90 minutes of ...
Of the 63 patients identified to have received tPA for acute ischemic stroke, 97% had at least one protocol deviation which is consistent across all hospitals studied.NovakDepartmentBarbaraDepartmentL.DepartmentForceDepartmentRexDepartmentW.Department...
Dr. Richard Burgess, a member of Dr. Warach’s stroke team, explained the situation: There is no particular penalty for not giving tPA. Doctors are unlikely to be sued if the patient dies or is left with brain damage that could have been avoided. But there is a penalty for giving tPA...
The NINDS t-PA for Acute Stroke Protocol Early intravenous Thrombolysis with recombinant tissue-type plasminogen activator in vertebrobasilar ischemic stroke. Arch Neurol 1998; 55: 466–469. CrossRef Albers GW, Bates V, Clark W, Bell R, Verro P, Hamilton S. Intravenous ... J Marler,PD Ly...
TPAProtocol Address of the Target TPATriangle Photographers Association TPATimber Producers Association of Michigan and Wisconsin TPATexas Pharmaceutical Association TPATrusted Parallel Application TPATechnology Program Annex TPATest Planning Analysis TPATiers Payant Assistance(French: Third-Party Payment) ...
Penumbra provided an unrestricted grant for the trial, and its devices were among those included in the protocol. Companies providing grants had no influence over the trial's design or execution. Penumbra's newest intra-arterial treatment, which was not available at the time MR CLEAN was conducte...
tPA and anticoagulation for treatment of severe frostbite have been reported suggesting differences in imaging techniques, route of tPA administration and management of patients after tPA infusion. This is a report of our results following a protocol of Tc-99m scanning, intravenous tPA administration,...
The CLOQS trial protocol: a cluster-randomized trial evaluating a simple, low-cost intervention to reduce treatment times in acute stroke RationaleIn acute stroke, time is brain: faster tissue plasminogen activator treatment improves patient outcomes. Published guidelines for door-to-scanner ... RH ...
The ethics of allowing off-protocol access to a study therapy are explored, using the example of recombinant factor VIIa for intracerebral hemorrhage. rVIIa was later found to be ineffective. While the studies were being performed, researchers struggled with the question of whether a critically ill...
for each cell. (b) Percentages of potentiation or inhibition after treatment are calculated for each cell and reported as percentages of responsiveness for each group. (c) In the same protocol, neurons were incubated for 45 min in the presence of buffer (control,n=75 cells), sc-tPA at ...