Thus, plasminogen and prothrombin must be cleaved into their two- chain form to display full enzymatic activity. In the vascular compartment, tissue plasminogen activator (tPA) mainly secreted by endothelial cells1 promotes fibrinolysis via the conversion of fibrin-bound plasminogen into plasmin. ...
“All these problems could be solved if there was a will to do it,” Dr. Sorensen said. In his opinion, it comes down to old and outdated assumptions that there is not much to be done for a stroke, to financial considerations and to a medical system that resists change. But the most...