The approved dose for tPA in acute ischemic stroke is 0.9mg/kg IV over an hr whereas for hemodynamically unstable pulmonary emboli, tPA is dosed at 100 IV over 2 hr (with a 10 mg IV bolus). Being such a rare presentation it would be a challenge to come up with recommendations...
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Commercially available recombinant tPA has already found application in the treatment of ischemic stroke, myocardial infarction and pulmonary embolism. The first report of the clinical use of tPA for thrombolysis in treating frostbite in humans occurredng in 1992 [7]. Since then, reports of the ...
How Activase is given or administered depends upon the patient’s weight and what it is being used to treat (such as a stroke, pulmonary embolism, or myocardial infarction. For example, when used to treat a heart attack (myocardial infarction), there are two Activase dose regimens, an accele...
INTRODUCTION: Thrombolytics are the mainstay of therapy for ST-elevation MI (STEMI) and ischemic stroke in low-and-middle-income countries (LMICs) without access to angiography. Streptokinase and alteplase (tPA) are delivered as small vo... RR Malya,Kevin P. Jackson,Jinwook Jung,... 被引...
"The discrepancy could be a matter of experimental design or dose," Yepes says. "Our results do suggest that the dose of tPA that is needed for a neuroprotective effect is significantly lower that the dose that we give to destroy the clot in our stroke patients." ...
Thrombolysis is increasingly being used in treating acute ischemic stroke but it is also accompanied with a serious complication of cerebral hemorrhage in ... Y Yi,L Qiu,A Shuaib - 《Neuropharmacology》 被引量: 279发表: 2000年 Annexin A2 combined with low-dose tPA improves thrombolytic therapy...
Dose adult Accelerated infusion (1.5 hours): Give 15 mg IV bolus Then give 50 mg infused over 30 min Then 35 mg infused over 60 min tissue plasminogen activator (tPA), alteplase Contraindications: Exclusion Characteristics of Patients With Ischemic Stroke Who Could Be Treated With tPA Within 3...
DESIGN: We report the first phase of the Argatroban tPA Stroke Study, an ongoing prospective, open-label, dose-escalation, safety and activity study of argatroban and rtPA in patients with ischemic stroke. The primary outcome was incidence of intracerebral hemorrhage; secondary outcome, complete ...
Mice were treated with either vehicle (Veh) or the PKCβ inhibitor (PKCβi; 10 mg/kg) once a day for 3 days and then subjected to MCAO followed by 1 additional dose of the inhibitor 1 hour later. (A) Twenty-four hours after MCAO, representative confocal images were obtained from the...