TP53 Mutation Heterogeneity Reveals Distinct Prognoses in Mantle Cell LymphomaBackground: Mantle cell lymphoma (MCL) is an uncommon and aggressive type of B-cell non-Hodgkin lymphoma, wherein TP53 mutations play a critical role. This study analyzed the effect of different TP53 mutations on the ...
参考文献 [1]Anita Kumar, Jacob Soumerai, Jeremy S. Abramson, et al. Zanubrutinib, obinutuzumab, and venetoclax for first-line treatment of mantle cell lymphoma with a TP53 mutation. Blood 2025; 145 (5): 497–507. ...
参考文献: Kumar A, Soumerai J, Abramson JS, et al. Zanubrutinib, obinutuzumab, and venetoclax for first-line treatment of mantle cell lymphoma with a TP53 mutation. Blood. 2025 Jan 30;145(5):497-507. doi: 10.1182/blood.2024...
关键词TP53突变；RFTA;套细胞淋巴瘤；;周亡 中图分类号R733.1 文献标识码 A d o i：10. 19746/j. cnki. issnl009 -2137.2021.06.015 Effect of RITA on TP53Mutant Human Mantle Cell Lymphoma Cell Line and Its Mechanism HUA Jia-Ye'", ZHOU Xu-Hong', WANG Yan1, XU Bing,A 1Department...
Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma. Int J Exp Pathol. 2005;86:347–63. Article CAS Google Scholar Jares P, Colomer D, Campo E. Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics. ...
In recent years, the outcome of mantle cell lymphoma has improved, especially in younger patients, receiving cytarabine-containing chemoimmunotherapy and autologous stem cell transplantation. Nevertheless, a proportion of mantle cell lymphoma patients still experience early failure. To identify biomarkers ant...
Christian Winther Eskelund, MD, Copenhagen University Hospital, Rigshospitalet, discusses TP53-mutated mantle cell lymphoma (MCL).Christian Winther Eskelund, MD, Copenhagen University Hospital, Rigshospitalet, discusses TP53-mutated mantle cell lymphoma (MCL). ...
TP53p21SOX11survivalMantle cell lymphoma (MCL) is characterized by the hallmark t(11;14)(q13;q32) translocation, leading to cyclin D1 over-expression. Additionally, disrupting the DNA damage response pathway through ATM or TP53 defects plays an important role in MCL pathogenesis. Using deep next...
mantlecelllymphomaTP53TP53 alterations portend extremely poor prognosis in patients with mantle cell lymphoma treated with standard treatment modalities. We reviewed outcomes of 42 patients with available TP53 status who had received a reduced‐intensity or non‐myeloablative allogeneic haematopoietic cell ...
Ikediobi et al., “Mutation analysis of 24 known cancer genes in the NCI-60 cell line set”, Mol Cancer Ther., 5(11):2606-2612, 2006. Lane et al., “p53-based cancer therapy,” Cold Spring Harb. Perspect. Biol., 2(9):a001222, 2010. ...