In contrast to TP53KO#30 cells, TP53KO#39 cells showed abnormal phenotypes. As observed in an early TP53-knockout mouse model, depletion of TP53 alone is not sufficient to induce transformation into cancerous cells [26]. Thus, abnormal characteristics of TP53KO#39 cells may be caused by ...
TP53 knockout mouse embryos show furthermore broad cranial defects involving skeletal, neural, and muscle tissues38. Similarly, mouse models for Treacher Collins syndrome (a disorder of cranial morphology which arises during early embryological development as a result of defects in the formation and ...
Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein p53 (TP53) are missense mutations1,2. Mutant p53 protein is often abundantly expressed in cancers and specific allelic variants exhibit dominant-negative or gain-of-
Six mice were injected with DIPG cells and treated with RG7388 (n = 3) or vehicle (n = 3) beginning on day 21 as previously described. These mice were sacrificed on day 42 and tumor samples were collected for immunofluorescence staining. The mouse brain was fixed in 10% formalin...
Employing TP53 wild-type cells, we generated models lacking RNF144B in both non-transformed and cancerous cells of human and mouse origin. By using proteomics, transcriptomics, and functional analysis, we assessed RNF144B's impact in cellular proliferation and transformation. Through in vitro and ...
喜欢 0 阅读量: 12 作者: Shai,Anny,Dankort,David,Green,Shon,Juan,Joseph,McMahon,Martin 展开 摘要: Lung carcinogenesis is a multistep process in whic 展开 年份: 2015 收藏 引用 批量引用 报错 分享 求助全文 通过文献互助平台发起求助,成功后即可免费获取论文全文。 请先登入 我们已与文献...
Immunoblotting was performed with: mouse monoclonal anti-Poly (ADP-ribose) polymerase (PARP) (cleaved form, BD Pharmingen), rabbit polyclonal anti-p53 (FL393) mouse monoclonal anti-p53 (DO1) (both from Santa Cruz Biotechnology), monoclonal anti-GFP (Roche Diagnostic), polyc...
1130Accesses Abstract Genomic aberrations and gene mutations are among the strongest prognostic factors in CLL. In particular, patients with mutatedTP53(TP53mut) and/or deleted chromosome 17p (del17p) have a worse response to therapy and significantly shorter progression-free survival (PFS) and over...
Koopal, SonjaUusivirta, SannaSawicki, JanetWei, Gong-HongKuznetsov, Sergey G.Scientific ReportsMunne, P.M., Gu, Y., Tumiati, M., et al. (2014). TP53 supports basal-like dif- ferentiation of mammary epithelial cells by preventing translocation of △Np63 into nucleoli. Sci. Rep. 4, ...
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. P Natl Acad Sci USA. 2013;110:E1480–E1489. Article CAS Google Scholar Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, et al. Senescence and tumour clearance is ...