Friedemann U, Elkeles A (1934) The blood-brain barrier in infectious diseases: Its permeability to toxins in relation to their electrical charges. Lancet 226:719–724Friedemann, U., and Elkeles, A. (1934). The blood-brain barrier in infectious dis- eases: its permeability to toxins in ...
The blood brain barrier is set up so there are specialized transporters (like pizza box slots) for all the required nutrients. So mostly, the only things that can get in are things that there are transporters for or things that look very similar (on a molecular scale). The analogy does f...
aAs we know, our body is so perfectly structured that all important organs are protected from external toxins by the so-called physiological drug barriers, such as the blood¨Cbrain barier and the gastrointestinal (GI) barrier. 我们知道的我们的身体首要的器官被保护免受外在毒素由所谓的生理药物障碍...
The brain is safeguarded from exogenous compounds through the blood-brain barrier (BBB). The potential of a toxin to enter the brain is an essential parameter when considering the toxicity, therefore, a BBB predictor was designed to determine whether a compound can cross the BBB. In silico dat...
An excellent book,Excitotoxins, by Russell Blaylock, describes how nerve cells either disintegrate or shrivel up in the presence of free glutamic acid if it gets past the blood-brain barrier. The glutamates in MSG are absorbed directly from the mouth to the brain. Some investigators believe th...
Further, it can breach the blood–brain barrier with intranasal delivery [39••]. Even more promising, synthetic circularized peptides derived from lynx1 and lynx1-like family members have been found to bind to α7 and the ectodomains of α9 nAChR subtypes [44••]. If it too ...
blood-brain-barrier; Bmk, Buthus martensii kirsch; BV, bee venom; BVPLA2, bee venom phospholipase A2; CNS, central nervous system; ECE-1, endothelin-converting-enzyme-1; FDA, Federal Drugs Administration; GFP, green fluosrescent protein; HD, Huntington's Disease; HWTX...
Acute encephalopathy with loss of blood brain barrier function, brain endothelial cell edema, and demyelination were predominant histologic features. Toxin antigen was detected in affected neurons, but it was not clear whether the neurologic symptoms were from primary neuronal lesions or...
[109]. The effect of uremic toxins was experimentally explored, and an increase in serum IS concentrations was shown to promote blood–brain barrier disruption associated with cognitive impairment by AhR activation in CKD rats established by an adenine-rich diet or by 5/6 nephrectomy [87]. ...
2.3.14. Spermine Promotes Breakdown of the Blood–Brain Barrier Polyamines disrupt the blood–brain barrier (BBB) under various pathological states [125,137–140]. Glantz et al. [138] reported that putrescine and spermidine, when injected into the carotid artery, caused a ...