Toxins 2020, 12(5), 291; https://doi.org/10.3390/toxins12050291 ActionDateNotesLink article xml file uploaded 4 May 2020 14:04 CEST Original file - article pdf uploaded. 4 May 2020 14:04 CEST Version of Record
It is known to cross the blood–brain barrier. The oral LD50 in rats is 750 mg/kg. Atropine exerts its pharmacodynamic effects by competitively blocking muscarinic acetylcholine receptor sites. Atropine or atropinic drugs result in pupil dilation, dry mouth, inhibition of activity of sweat glands...
Blood-Brain BarrierEndothelium, VascularAnimalsRabbitsHepatic EncephalopathyPolyethylene GlycolsPermeabilityToxins, BiologicalOur study was designed to determine whether substances that appear in the serum during the course of liver failure have a detrimental effect on the passive permeability of the blood-...
An excellent book,Excitotoxins, by Russell Blaylock, describes how nerve cells either disintegrate or shrivel up in the presence of free glutamic acid if it gets past the blood-brain barrier. The glutamates in MSG are absorbed directly from the mouth to the brain. Some investigators believe th...
The brain is safeguarded from exogenous compounds through the blood-brain barrier (BBB). The potential of a toxin to enter the brain is an essential parameter when considering the toxicity, therefore, a BBB predictor was designed to determine whether a compound can cross the BBB. In silico dat...
blood-brain-barrier; Bmk, Buthus martensii kirsch; BV, bee venom; BVPLA2, bee venom phospholipase A2; CNS, central nervous system; ECE-1, endothelin-converting-enzyme-1; FDA, Federal Drugs Administration; GFP, green fluosrescent protein; HD, Huntington's Disease; HWTX...
Several factors are involved, including hemodynamic disorders and blood-brain barrier (BBB) impairment. The BBB guarantees the exchange of solutes between the blood and the brain through a complex cellular organization and a diverse range of transport proteins. We hypothesize that the increased ...
2.3.14. Spermine Promotes Breakdown of the Blood–Brain Barrier Polyamines disrupt the blood–brain barrier (BBB) under various pathological states [125,137–140]. Glantz et al. [138] reported that putrescine and spermidine, when injected into the carotid artery, caused a ...
Penetration of the blood-brain barrier can be accomplished by linking large particles to iron transferrin or biological toxins that can cross the barrier. ... RS Fisher,J Ho - 《Cns Drugs》 被引量: 150发表: 2002年 Chemistry, Etiology and Determination Methods of Ciguatera Toxins Ciguatera refer...
Further, it can breach the blood–brain barrier with intranasal delivery [39••]. Even more promising, synthetic circularized peptides derived from lynx1 and lynx1-like family members have been found to bind to α7 and the ectodomains of α9 nAChR subtypes [44••]. If it too ...