Keywords: persistence, programmed cell death, toxin–antitoxin system, stress. Introduction Almost all bacteria possess genes whose expression can inhibit cell growth and even result in cell death when over expressed, reflecting similarities to eukaryotic programmed cell death or apoptosis. Among thos...
The Hha-TomB Toxin-Antitoxin System Shows Conditional Toxicity and Promotes Persister Cell Formation by Inhibiting Apoptosis-Like Death in S. Typhimurium Toxin-antitoxin (TA) modules are two component "addictive" genetic elements found on either plasmid or bacterial chromosome, sometimes on both. TA ...
www.nature.com/scientificreports OPEN The Hha-TomB Toxin-Antitoxin System Shows Conditional Toxicity and Promotes Persister Cell received: 23 February 2016 Formation by Inhibiting Apoptosis-accepted:03June2016 Like Death in S. TyphimuriumPublished:02December2016 Sangeeta Jaiswal, Prajita Paul, ...
(HayesandSauer,2003;Magnuson,2007;SaavedraDeBastetal.,2008;Tsilibarisetal.,2007).Anumberofputativefunctionshavebeenascribedtothechromosome-encodedTAloci,includingbacterialapoptosis,genomeshufflingandcellcyclearrest,butthemostpopularhypothesisisthattheyareinvolvedinageneralstressresponse,assuggestedbyextensivestudieson...
Increasing the Ability of Attenuated Bacteria to Elicit Effective Anti-Tumor Cellular Immunity and Apoptosis of Tumor Cells The success of tumor growth and metastasis in cancer patients is related to the suppression of their immune system, mainly by inhibition of T cell functions. To elicit a high...
1G.The Hha/TomB TA system acting as an oxygen sensor (Marimon et al., 2016) refers to its relevance for biofilms so that the bacterial cells under anoxic conditions would show reduced growth on account of Hha toxin activity. HepT/MntA is another example of an enzyme antitoxin. A set of...
(in most cases, by destroying mRNA). As a result, bacterial growth ceases. In accordance with one group of the data, long-term inhibition of growth of most cells results in their programmed death and destruction, corresponding to apoptosis; this allows a minor part of the population to ...
The toxin and antitoxins are encoded by a two-component toxin-antitoxin (TA) system. The antitoxin, a protein or RNA, sequesters the toxins of the TA system for neutralization within the bacterial cell. In this review, we have described different TA systems of bacteria and their potential ...
Till stress do us ataRT: a novel toxin-antitoxin system targeting translation initiationCell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis. It provides a single accessible source of information for both scientists and ...
Apoptosis-like death, an extreme SOS response in Escherichia coli. mBio 2014, 5. [Google Scholar] [CrossRef] [PubMed] Erental, A.; Sharon, I.; Engelberg-Kulka, H. Two programmed cell death systems in Escherichia coli: An apoptotic-like death is inhibited by the mazEF-mediated death ...